HNRC4_HUMAN
ID HNRC4_HUMAN Reviewed; 293 AA.
AC P0DMR1;
DT 26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT 26-NOV-2014, sequence version 1.
DT 03-AUG-2022, entry version 48.
DE RecName: Full=Heterogeneous nuclear ribonucleoprotein C-like 4 {ECO:0000312|HGNC:HGNC:51333};
GN Name=HNRNPCL4 {ECO:0000312|HGNC:HGNC:51333};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P07910}.
CC -!- SIMILARITY: Belongs to the RRM HNRPC family. RALY subfamily.
CC {ECO:0000305}.
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DR EMBL; AC245056; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS76107.1; -.
DR RefSeq; NP_001139653.1; NM_001146181.2.
DR RefSeq; NP_001289480.1; NM_001302551.1.
DR AlphaFoldDB; P0DMR1; -.
DR SMR; P0DMR1; -.
DR IntAct; P0DMR1; 1.
DR iPTMnet; P0DMR1; -.
DR PhosphoSitePlus; P0DMR1; -.
DR BioMuta; HNRNPCL4; -.
DR EPD; P0DMR1; -.
DR jPOST; P0DMR1; -.
DR MassIVE; P0DMR1; -.
DR MaxQB; P0DMR1; -.
DR PeptideAtlas; P0DMR1; -.
DR PRIDE; P0DMR1; -.
DR DNASU; 101060301; -.
DR Ensembl; ENST00000323770.8; ENSP00000485450.2; ENSG00000179412.11.
DR Ensembl; ENST00000633805.3; ENSP00000488276.1; ENSG00000282095.3.
DR Ensembl; ENST00000637294.3; ENSP00000490926.1; ENSG00000283231.3.
DR GeneID; 101060301; -.
DR GeneID; 649330; -.
DR KEGG; hsa:101060301; -.
DR MANE-Select; ENST00000323770.8; ENSP00000485450.2; NM_001302551.2; NP_001289480.1.
DR MANE-Select; ENST00000617807.3; ENSP00000478017.1; NM_001382358.1; NP_001369287.1.
DR UCSC; uc031tpp.2; human.
DR CTD; 101060301; -.
DR CTD; 649330; -.
DR GeneCards; HNRNPCL4; -.
DR HGNC; HGNC:51333; HNRNPCL4.
DR HPA; ENSG00000179412; Not detected.
DR neXtProt; NX_P0DMR1; -.
DR OpenTargets; ENSG00000277058; -.
DR VEuPathDB; HostDB:ENSG00000179412; -.
DR GeneTree; ENSGT00940000153402; -.
DR HOGENOM; CLU_079090_0_0_1; -.
DR OrthoDB; 1211602at2759; -.
DR PathwayCommons; P0DMR1; -.
DR BioGRID-ORCS; 101060301; 3 hits in 75 CRISPR screens.
DR BioGRID-ORCS; 649330; 6 hits in 146 CRISPR screens.
DR Pharos; P0DMR1; Tdark.
DR PRO; PR:P0DMR1; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; P0DMR1; protein.
DR Bgee; ENSG00000179412; Expressed in ventricular zone and 1 other tissue.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR017347; hnRNP_C.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 1.
DR PIRSF; PIRSF037992; hnRNP-C_Raly; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW Coiled coil; Nucleus; Reference proteome; RNA-binding.
FT CHAIN 1..293
FT /note="Heterogeneous nuclear ribonucleoprotein C-like 4"
FT /id="PRO_0000431380"
FT DOMAIN 16..87
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 140..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 208..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 177..208
FT /evidence="ECO:0000255"
FT COMPBIAS 145..168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..244
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..263
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 293 AA; 32029 MW; DFE7DF4E2B233CC4 CRC64;
MASNVTNKMD PHSMNSRVFI GNLNTLVVKK SDVEAIFSKY GKIAGCSVHK GFAFVQYDKE
KNARAAVAGE DGRMIASQVV DINLAAEPKV NRGNAGVKRS AAEMYGSSFD LDYNLQRDYY
GGMYSFPARV PPPPPIALAV VPSKRQRISG NTSRRGKSGF NSKSGKRGSS KSGKLKGDDL
QAIKQELTQI KQKVDSLLEN LEKIEKEHCK QGVEVKNAKS EEEQTSSSSK KDKTHVKMES
EGGADDSVEE GDLLCDDDNE DQGDNQLELI KDDEKGAEEG EDDRDRANGQ DDS
