HNRC1_HUMAN
ID HNRC1_HUMAN Reviewed; 293 AA.
AC O60812; B2RP44;
DT 02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 179.
DE RecName: Full=Heterogeneous nuclear ribonucleoprotein C-like 1;
DE Short=hnRNP C-like-1;
DE AltName: Full=hnRNP core protein C-like 1;
GN Name=HNRNPCL1; Synonyms=HNRPCL1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in nucleosome assembly by neutralizing basic
CC proteins such as A and B core hnRNPs. {ECO:0000250}.
CC -!- INTERACTION:
CC O60812; A1L168: C20orf202; NbExp=3; IntAct=EBI-1046507, EBI-18396958;
CC O60812; P07910: HNRNPC; NbExp=3; IntAct=EBI-1046507, EBI-357966;
CC O60812; O60812: HNRNPCL1; NbExp=3; IntAct=EBI-1046507, EBI-1046507;
CC O60812; B2RXH8: HNRNPCL2; NbExp=3; IntAct=EBI-1046507, EBI-9512317;
CC O60812; O75928-2: PIAS2; NbExp=3; IntAct=EBI-1046507, EBI-348567;
CC O60812; Q9Y4B4: RAD54L2; NbExp=3; IntAct=EBI-1046507, EBI-948156;
CC O60812; Q53GL6: RALY; NbExp=3; IntAct=EBI-1046507, EBI-9512693;
CC O60812; Q86SE5-3: RALYL; NbExp=3; IntAct=EBI-1046507, EBI-11526555;
CC O60812; P78317: RNF4; NbExp=3; IntAct=EBI-1046507, EBI-2340927;
CC O60812; Q7KZS0: UBE2I; NbExp=3; IntAct=EBI-1046507, EBI-10180829;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Component of
CC ribonucleosomes. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RRM HNRPC family. RALY subfamily.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL022101; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471130; EAW71752.1; -; Genomic_DNA.
DR EMBL; BC137258; AAI37259.1; -; mRNA.
DR EMBL; BC171866; AAI71866.1; -; mRNA.
DR CCDS; CCDS30591.1; -.
DR RefSeq; NP_001013653.1; NM_001013631.2.
DR AlphaFoldDB; O60812; -.
DR SMR; O60812; -.
DR BioGRID; 131227; 174.
DR IntAct; O60812; 63.
DR MINT; O60812; -.
DR STRING; 9606.ENSP00000479365; -.
DR GlyGen; O60812; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; O60812; -.
DR PhosphoSitePlus; O60812; -.
DR SwissPalm; O60812; -.
DR BioMuta; HNRNPCL1; -.
DR EPD; O60812; -.
DR jPOST; O60812; -.
DR MassIVE; O60812; -.
DR MaxQB; O60812; -.
DR PaxDb; O60812; -.
DR PeptideAtlas; O60812; -.
DR PRIDE; O60812; -.
DR ProteomicsDB; 49605; -.
DR Antibodypedia; 65448; 114 antibodies from 18 providers.
DR DNASU; 343069; -.
DR Ensembl; ENST00000317869.7; ENSP00000365370.4; ENSG00000179172.10.
DR Ensembl; ENST00000634171.3; ENSP00000488130.1; ENSG00000282175.4.
DR GeneID; 343069; -.
DR KEGG; hsa:343069; -.
DR MANE-Select; ENST00000317869.7; ENSP00000365370.4; NM_001013631.3; NP_001013653.1.
DR UCSC; uc010obf.2; human.
DR CTD; 343069; -.
DR GeneCards; HNRNPCL1; -.
DR HGNC; HGNC:29295; HNRNPCL1.
DR HPA; ENSG00000179172; Not detected.
DR neXtProt; NX_O60812; -.
DR OpenTargets; ENSG00000179172; -.
DR PharmGKB; PA162391240; -.
DR VEuPathDB; HostDB:ENSG00000179172; -.
DR eggNOG; KOG0118; Eukaryota.
DR GeneTree; ENSGT00940000153402; -.
DR HOGENOM; CLU_079090_0_0_1; -.
DR InParanoid; O60812; -.
DR OMA; MECEGGA; -.
DR OrthoDB; 1315388at2759; -.
DR PhylomeDB; O60812; -.
DR TreeFam; TF330974; -.
DR PathwayCommons; O60812; -.
DR SignaLink; O60812; -.
DR BioGRID-ORCS; 343069; 101 hits in 986 CRISPR screens.
DR GenomeRNAi; 343069; -.
DR Pharos; O60812; Tdark.
DR PRO; PR:O60812; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; O60812; protein.
DR Bgee; ENSG00000179172; Expressed in skeletal muscle tissue of biceps brachii and 24 other tissues.
DR Genevisible; O60812; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR017347; hnRNP_C.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 1.
DR PIRSF; PIRSF037992; hnRNP-C_Raly; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Nucleus; Reference proteome; Ribonucleoprotein; RNA-binding.
FT CHAIN 1..293
FT /note="Heterogeneous nuclear ribonucleoprotein C-like 1"
FT /id="PRO_0000081848"
FT DOMAIN 16..87
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 137..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 177..225
FT /evidence="ECO:0000255"
FT COMPBIAS 145..168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..244
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..263
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..293
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 81
FT /note="D -> V (in dbSNP:rs2982092)"
FT /id="VAR_059824"
FT VARIANT 208
FT /note="Q -> H (in dbSNP:rs6702447)"
FT /id="VAR_052225"
FT VARIANT 258
FT /note="V -> D (in dbSNP:rs2076063)"
FT /id="VAR_033723"
SQ SEQUENCE 293 AA; 32142 MW; C87938AE3189D8E2 CRC64;
MASNVTNKMD PHSMNSRVFI GNLNTLVVKK SDVEAIFSKY GKIAGCSVHK GFAFVQYDKE
KNARAAVAGE DGRMIASQVV DINLAAEPKV NRGNAGVKRS AAEMYGSSFD LDYGFQRDYY
DGMYSFPARV PPPPPIALAV VPSKRQRLSG NTSRRGKSGF NSKSGKRGSS KSGKLKGDDL
QAIKQELTQI KQKVDSLLEN LEKIEKEQSK QEVEVKNAKS EEEQSSSSMK KDETHVKMES
EGGAEDSAEE GDPLDDDVNE DQGDDQLELI KDDEKEAEEG EDDRDSTNGQ DDS
