ID   HNK2_XENLA              Reviewed;         196 AA.
AC   P42587;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Homeobox protein XENK-2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryonic head;
RX   PubMed=8104140; DOI=10.1242/dev.118.1.193;
RA   Saha M.S., Michel R.B., Gulding K.M., Grainger R.M.;
RT   "A Xenopus homeobox gene defines dorsal-ventral domains in the developing
RT   brain.";
RL   Development 118:193-202(1993).
CC   -!- FUNCTION: Defines dorsal-ventral domains in developing brain. May play
CC       a role in defining positional information along the anterior-posterior
CC       (a/p) axis and the dorsal-ventral (d/v) axis of the developing nervous
CC       system. May be involved in determining positional or boundary
CC       information rather than determining a given cell type.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Forebrain and midbrain.
CC   -!- DEVELOPMENTAL STAGE: Is first detectable at the neural plate stage
CC       (stage 14). Levels gradually increase during later neurula stages, and
CC       becomes fairly constant throughout tailbud and hatching stages before
CC       declining at late swimming tadpole stages.
CC   -!- SIMILARITY: Belongs to the NK-2 homeobox family. {ECO:0000305}.
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DR   EMBL; L10327; AAA72342.1; -; mRNA.
DR   EMBL; S65507; AAB28271.2; -; mRNA.
DR   RefSeq; NP_001079091.1; NM_001085622.1.
DR   AlphaFoldDB; P42587; -.
DR   SMR; P42587; -.
DR   GeneID; 373624; -.
DR   KEGG; xla:373624; -.
DR   CTD; 373624; -.
DR   Xenbase; XB-GENE-864842; nkx2-2.S.
DR   Proteomes; UP000186698; Chromosome 5S.
DR   Bgee; 373624; Expressed in neurula embryo and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..196
FT                   /note="Homeobox protein XENK-2"
FT                   /id="PRO_0000049127"
FT   DNA_BIND        69..128
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          48..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        51..72
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   196 AA;  22809 MW;  F5A0657470C1031B CRC64;
     MPLKSPFYDS SDNLIHDGWL LLRASNTPCT VLRPEIRSRF LLLSLQKPSA DESPDNDKEL
     SSNPDSGKKR KRRVLFSKAQ TYELERRFRQ QRYLSAPERE HLASLIRLTP TQVKIWFQNH
     RYKMKRARSE KGMEVTPLPS PRRVAVPVLV RDGKPCHTLK AQDFNPATFP TGIPFSAYSA
     QSLHHMQYNA QFLFYH