HNFAA_XENLA
ID HNFAA_XENLA Reviewed; 605 AA.
AC Q05041;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Hepatocyte nuclear factor 1-alpha-A;
DE Short=HNF-1-alpha-A;
DE Short=HNF-1A-A;
DE AltName: Full=LFB1;
DE AltName: Full=Transcription factor 1-A;
DE Short=TCF-1-A;
DE AltName: Full=XLFB1a;
GN Name=hnf1a-a; Synonyms=hnf1-a, lfb1a, tcf1-a;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RX PubMed=8417340; DOI=10.1128/mcb.13.1.421-431.1993;
RA Bartkowski S., Zapp D., Weber H., Eberle G., Zoidl C., Senkel S.,
RA Klein-Hitpass L., Ryffel G.U.;
RT "Developmental regulation and tissue distribution of the liver
RT transcription factor LFB1 (HNF1) in Xenopus laevis.";
RL Mol. Cell. Biol. 13:421-431(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RX PubMed=8262383; DOI=10.1016/0378-1119(93)90102-9;
RA Zapp D., Bartkowski S., Zoidl C., Klein-Hitpass L., Ryffel G.U.;
RT "Genomic structure of the Xenopus laevis liver transcription factor LFB1.";
RL Gene 134:251-256(1993).
RN [3]
RP FUNCTION.
RX PubMed=8735941;
RA Weber H., Pogge von Strandmann E., Holewa B., Bartkowski S., Zapp D.,
RA Zoidl C., Ryffel G.U.;
RT "Regulation and function of the tissue-specific transcription factor HNF1
RT alpha (LFB1) during Xenopus development.";
RL Int. J. Dev. Biol. 40:297-304(1996).
CC -!- FUNCTION: Transcriptional activator that regulates the tissue specific
CC expression of multiple genes, especially in pancreas and liver (By
CC similarity). Binds to the hepatocyte specific promoter element HP1.
CC Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. {ECO:0000250,
CC ECO:0000269|PubMed:8735941}.
CC -!- SUBUNIT: Binds DNA as dimer. Forms a homodimer or heterodimer with
CC HNF1-alpha-B. Potentially also form a heterodimer with HNF1-beta.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Protein expressed in liver, stomach, small
CC intestine, colon and kidney. Not expressed in spleen, lung, blood,
CC heart muscle, skeletal muscle, testis and brain.
CC -!- DEVELOPMENTAL STAGE: Protein found in 2-day-old hatched larvae (stage
CC 35).
CC -!- SIMILARITY: Belongs to the HNF1 homeobox family. {ECO:0000305}.
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DR EMBL; X64759; CAA46007.1; -; mRNA.
DR PIR; A48115; A48115.
DR PIR; T01067; T01067.
DR RefSeq; NP_001095214.1; NM_001101744.1.
DR AlphaFoldDB; Q05041; -.
DR SMR; Q05041; -.
DR GeneID; 378589; -.
DR KEGG; xla:378589; -.
DR CTD; 378589; -.
DR Xenbase; XB-GENE-865049; hnf1a.S.
DR OrthoDB; 409935at2759; -.
DR Proteomes; UP000186698; Chromosome 1S.
DR Bgee; 378589; Expressed in pancreas and 4 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030073; P:insulin secretion; IEA:InterPro.
DR GO; GO:0001889; P:liver development; IEA:InterPro.
DR GO; GO:0031016; P:pancreas development; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR039066; HNF-1.
DR InterPro; IPR006899; HNF-1_N.
DR InterPro; IPR044869; HNF-1_POU.
DR InterPro; IPR023219; HNF1_dimer_N_dom_sf.
DR InterPro; IPR006898; HNF1a_C.
DR InterPro; IPR006897; HNF1b_C.
DR InterPro; IPR044866; HNF_P1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR PANTHER; PTHR11568; PTHR11568; 1.
DR Pfam; PF04814; HNF-1_N; 1.
DR Pfam; PF04813; HNF-1A_C; 1.
DR Pfam; PF04812; HNF-1B_C; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF100957; SSF100957; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF47413; SSF47413; 1.
DR PROSITE; PS51937; HNF_P1; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS51936; POU_4; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..605
FT /note="Hepatocyte nuclear factor 1-alpha-A"
FT /id="PRO_0000049119"
FT DOMAIN 1..32
FT /note="HNF-p1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01286"
FT DOMAIN 85..180
FT /note="POU-specific atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01285"
FT DNA_BIND 202..282
FT /note="Homeobox; HNF1-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..31
FT /note="Dimerization"
FT /evidence="ECO:0000250"
FT REGION 57..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 128..130
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT REGION 141..147
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT REGION 153..156
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT REGION 206..209
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT REGION 266..268
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT REGION 273..276
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT REGION 321..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..453
FT /note="Not present in other members of the HNF1 family"
FT MOTIF 200..208
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
SQ SEQUENCE 605 AA; 66577 MW; 946A5E873B9A686B CRC64;
MASQLSYLQR ELLQALLESG VTKEALKKAL ADGDDYTYPN VPLDDIRNLD EGENCVQLPN
GLGESHISED ESSDDGEDFT PPIMKELERL SPEEAAHQKA VVERLLQEDS WHVAKLVKSY
LQQHNIPQRE VVETTGLNQS HLSQHLNKGT PMKTQKRAAL YTWYVGKQRE IARLFTFTEF
THAGQGLITD DMSCDEVPTK KMRRNRFKWG PASQQILFQA YERQKNPSKE EREALVEECN
RAECLQRGVS PSQAQGLGSN LVTEVRVYNW FANRRKEEAF RHKLAMDTYN GQQNSAPTLS
AHDLPHGKTY GFRYIQDSST DRSAVMANSQ STPSPSALEP SHSLMNSDSK MIPVSGGSLP
PVSTLTALHN VDHSQHTLGQ TQNLIMASLP SVMTIGTDTA LGPAFSNPGS STLVIGLASQ
TQSVPVINSV GSSLTTLQSV QFSQQLHPSH QLHPSHQQPI VQQVQSHMAQ NPFMATMAQL
QSPHAIYSHK PDVAQYASAG FFPQTMVITD TSNLGTLTSL TPSKQVVPLH TTAHGDAPGS
QLQNQDSSIL HLPLCHRLSP IPTVSSASLV HYHNSSSPEN HSHLLSPSHN TIDSFISTQM
ASSSQ
