HNF4G_MOUSE
ID HNF4G_MOUSE Reviewed; 408 AA.
AC Q9WUU6;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 2.
DT 25-MAY-2022, entry version 173.
DE RecName: Full=Hepatocyte nuclear factor 4-gamma;
DE Short=HNF-4-gamma;
DE AltName: Full=Nuclear receptor subfamily 2 group A member 2;
GN Name=Hnf4g; Synonyms=Nr2a2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10786614; DOI=10.1016/s0167-4781(99)00232-8;
RA Taraviras S., Mantamadiotis T., Dong-Si T., Mincheva A., Lichter P.,
RA Drewes T., Ryffel G.U., Monaghan A.P., Schutz G.;
RT "Primary structure, chromosomal mapping, expression and transcriptional
RT activity of murine hepatocyte nuclear factor 4gamma.";
RL Biochim. Biophys. Acta 1490:21-32(2000).
CC -!- FUNCTION: Transcription factor. Has a lower transcription activation
CC potential than HNF4-alpha (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR2
CC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB43724.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AJ242626; CAB43724.1; ALT_INIT; mRNA.
DR CCDS; CCDS17226.1; -.
DR RefSeq; NP_038948.1; NM_013920.2.
DR AlphaFoldDB; Q9WUU6; -.
DR SMR; Q9WUU6; -.
DR BioGRID; 206019; 6.
DR IntAct; Q9WUU6; 6.
DR STRING; 10090.ENSMUSP00000104031; -.
DR iPTMnet; Q9WUU6; -.
DR PhosphoSitePlus; Q9WUU6; -.
DR MaxQB; Q9WUU6; -.
DR PaxDb; Q9WUU6; -.
DR PRIDE; Q9WUU6; -.
DR ProteomicsDB; 269608; -.
DR DNASU; 30942; -.
DR GeneID; 30942; -.
DR KEGG; mmu:30942; -.
DR CTD; 3174; -.
DR MGI; MGI:1353604; Hnf4g.
DR eggNOG; KOG4215; Eukaryota.
DR InParanoid; Q9WUU6; -.
DR Reactome; R-MMU-383280; Nuclear Receptor transcription pathway.
DR BioGRID-ORCS; 30942; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Hnf4g; mouse.
DR PRO; PR:Q9WUU6; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q9WUU6; protein.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0045171; C:intercellular bridge; ISO:MGI.
DR GO; GO:0072686; C:mitotic spindle; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005667; C:transcription regulator complex; ISS:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Receptor;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..408
FT /note="Hepatocyte nuclear factor 4-gamma"
FT /id="PRO_0000053563"
FT DOMAIN 99..328
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 9..84
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 12..32
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 48..72
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 369..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..408
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 94
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P22449"
FT MOD_RES 370
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P49698"
FT MOD_RES 373
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P49698"
FT MOD_RES 377
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P49698"
SQ SEQUENCE 408 AA; 45897 MW; 5E4AF2E53BCDC7F1 CRC64;
MNTTDSGVNC LCAICGDRAT GKHYGASSCD GCKGFFRRSI RKSHVYSCRF SRQCVVDKDK
RNQCRYCRLR KCFRAGMKKE AVQNERDRIS TRRSTYEGSN IPSINTLAQA EVRSCQISVP
SPSSSTDINI KKIASISDVC ESMKQQLLVL VEWAKYIPAF CELPLDDQVA LLRAHAGEHL
LLGATKRSMM YKDILLLGNH YVIHRNSCEV EVSRVANRVL DELVRPFQEI QIDDNEYACL
KAIVFFDPDA KGLSDPVKIK NMRFQVQISL EDYINDRQYD SRGRFGELLL LLPTLQSITW
QMIEQIQFVK LFGMVKIDNL LQEMLLGGAA NDGSHLHHPM HPHLSQDPLT GQTILLGPMS
TLVHTDQIAT PETPLPSPPQ GSGQEPYKIT ANQASVISHQ SLSKQKQL
