HM12_CAEEL
ID HM12_CAEEL Reviewed; 180 AA.
AC P17487; Q9TZZ7;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2002, sequence version 2.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Homeobox protein ceh-12;
GN Name=ceh-12; ORFNames=F33D11.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 154-180.
RX PubMed=1970877; DOI=10.1093/nar/18.8.2033;
RA Schaller D., Wittmann C., Spicher A., Mueller F., Tobler H.;
RT "Cloning and analysis of three new homeobox genes from the nematode
RT Caenorhabditis elegans.";
RL Nucleic Acids Res. 18:2033-2036(1990).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR EMBL; FO080753; CCD66437.1; -; Genomic_DNA.
DR EMBL; X17076; CAA34928.1; -; Genomic_DNA.
DR PIR; S09504; S09504.
DR PIR; T32764; T32764.
DR RefSeq; NP_491693.1; NM_059292.1.
DR AlphaFoldDB; P17487; -.
DR SMR; P17487; -.
DR BioGRID; 37709; 3.
DR IntAct; P17487; 3.
DR STRING; 6239.F33D11.4; -.
DR PaxDb; P17487; -.
DR EnsemblMetazoa; F33D11.4a.1; F33D11.4a.1; WBGene00000436.
DR GeneID; 172255; -.
DR KEGG; cel:CELE_F33D11.4; -.
DR UCSC; F33D11.4; c. elegans.
DR CTD; 172255; -.
DR WormBase; F33D11.4a; CE09894; WBGene00000436; ceh-12.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000164719; -.
DR HOGENOM; CLU_126728_0_0_1; -.
DR InParanoid; P17487; -.
DR OrthoDB; 1600818at2759; -.
DR PRO; PR:P17487; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00000436; Expressed in larva and 2 other tissues.
DR ExpressionAtlas; P17487; baseline.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR GO; GO:0048812; P:neuron projection morphogenesis; IBA:GO_Central.
DR GO; GO:0021520; P:spinal cord motor neuron cell fate specification; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR042768; MNX1/Ceh-12.
DR PANTHER; PTHR24335; PTHR24335; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 4: Predicted;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..180
FT /note="Homeobox protein ceh-12"
FT /id="PRO_0000048987"
FT DNA_BIND 110..169
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 15..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 180 AA; 20296 MW; FC2117756F8D4376 CRC64;
MMFSSIDSLL KISTSSQNED QKLESHPSPP SQIPNYSTSC SEELMKMAAK AAQFAAQASL
ENSFSSSTSP TSTVTPLSAY TSLVQPVLPL IYDHLALTYS VNAWQAWGKM RRPRTAFSSE
QLVQLEKQFS DNRYLSRPRR YQLAQQLSLS ETQIKIWFQN RRMKNKRCPS STPIQSTSSS
