HLH17_CAEEL
ID HLH17_CAEEL Reviewed; 101 AA.
AC O45489;
DT 02-DEC-2020, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 3.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Helix-loop-helix protein 17 {ECO:0000312|WormBase:F38C2.2};
GN Name=hlh-17 {ECO:0000312|WormBase:F38C2.2};
GN ORFNames=F38C2.2 {ECO:0000312|WormBase:F38C2.2};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=16014321; DOI=10.1016/j.gene.2005.05.003;
RA McMiller T.L., Johnson C.M.;
RT "Molecular characterization of HLH-17, a C. elegans bHLH protein required
RT for normal larval development.";
RL Gene 356:1-10(2005).
RN [3] {ECO:0000305}
RP FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=18508862; DOI=10.1242/dev.019547;
RA Yoshimura S., Murray J.I., Lu Y., Waterston R.H., Shaham S.;
RT "mls-2 and vab-3 Control glia development, hlh-17/Olig expression and glia-
RT dependent neurite extension in C. elegans.";
RL Development 135:2263-2275(2008).
RN [4] {ECO:0000305}
RP FUNCTION.
RX PubMed=21688290; DOI=10.1002/jnr.22694;
RA Felton C.M., Johnson C.M.;
RT "Modulation of dopamine-dependent behaviors by the Caenorhabditis elegans
RT Olig homolog HLH-17.";
RL J. Neurosci. Res. 89:1627-1636(2011).
CC -!- FUNCTION: Probable transcription factor that regulates the expression
CC of dopamine receptors dop-1, dop-2 and dop-3 and thus dopamine-
CC dependent behaviors (PubMed:18508862, PubMed:21688290). May act
CC redundantly with hlh-31 and hlh-32 to regulate ventral CEPsh glia
CC functions (PubMed:18508862). May play a role in chemotactic responses
CC in larvae (PubMed:16014321, PubMed:21688290).
CC {ECO:0000269|PubMed:16014321, ECO:0000269|PubMed:18508862,
CC ECO:0000269|PubMed:21688290}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- TISSUE SPECIFICITY: Expressed in neuronal tissues of the head,
CC including sheath cells of the cephalic sensilla (CEPsh) glia.
CC {ECO:0000269|PubMed:16014321, ECO:0000269|PubMed:18508862}.
CC -!- DEVELOPMENTAL STAGE: Expressed in embryos and during larval development
CC (PubMed:16014321). Expressed strongly in cephalic sheath (CEPsh) glia
CC at all developmental stages and in some motoneurons of the ventral cord
CC in larvae (PubMed:18508862). {ECO:0000269|PubMed:16014321,
CC ECO:0000269|PubMed:18508862}.
CC -!- DISRUPTION PHENOTYPE: Expression in ventral CEPsh glia is normal in
CC knockout, but significantly reduced on a vab-3(ns157) mutant background
CC (PubMed:18508862). RNAi-mediated knockdown causes egg-laying defects
CC (PubMed:16014321). {ECO:0000269|PubMed:16014321,
CC ECO:0000269|PubMed:18508862}.
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DR EMBL; BX284604; CAB05189.3; -; Genomic_DNA.
DR RefSeq; NP_502928.3; NM_070527.4.
DR AlphaFoldDB; O45489; -.
DR SMR; O45489; -.
DR IntAct; O45489; 1.
DR STRING; 6239.F38C2.2; -.
DR PaxDb; O45489; -.
DR EnsemblMetazoa; F38C2.2.1; F38C2.2.1; WBGene00001961.
DR GeneID; 185460; -.
DR KEGG; cel:CELE_F38C2.2; -.
DR UCSC; F38C2.2; c. elegans.
DR CTD; 185460; -.
DR WormBase; F38C2.2; CE42757; WBGene00001961; hlh-17.
DR eggNOG; KOG3898; Eukaryota.
DR GeneTree; ENSGT00940000168751; -.
DR HOGENOM; CLU_169863_0_0_1; -.
DR InParanoid; O45489; -.
DR OMA; LMQANAM; -.
DR OrthoDB; 1617813at2759; -.
DR PhylomeDB; O45489; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00001961; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0032226; P:positive regulation of synaptic transmission, dopaminergic; IMP:WormBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:WormBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..101
FT /note="Helix-loop-helix protein 17"
FT /id="PRO_0000451454"
FT DOMAIN 14..68
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 14..27
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 28..68
FT /note="Helix-loop-helix motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
SQ SEQUENCE 101 AA; 11301 MW; DB865F9AE0C8E9DA CRC64;
MEKIGIDTAF AEPGVRLSIN LRERCRMHDL NEALDDLRAV IPYAHGGSVR KLSKIATLLL
AKNHIIMQAK AIEELSILVS QLKRKSENLE NLNKSLKPDA N
