ID   HIS7_STRCO              Reviewed;         197 AA.
AC   P16247;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   25-MAY-2022, entry version 131.
DE   RecName: Full=Imidazoleglycerol-phosphate dehydratase;
DE            Short=IGPD;
DE            EC=4.2.1.19;
GN   Name=hisB; OrderedLocusNames=SCO2052; ORFNames=SC4G6.21c;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A3(2) / NRRL B-16638;
RX   PubMed=2199329; DOI=10.1016/0378-1119(90)90436-u;
RA   Limauro D., Avitabile A., Cappellano M., Puglia A.M., Bruni C.B.;
RT   "Cloning and characterization of the histidine biosynthetic gene cluster of
RT   Streptomyces coelicolor A3(2).";
RL   Gene 90:31-41(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-
CC         4-yl)-2-oxopropyl phosphate + H2O; Xref=Rhea:RHEA:11040,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:57766, ChEBI:CHEBI:58278; EC=4.2.1.19;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the imidazoleglycerol-phosphate dehydratase
CC       family. {ECO:0000305}.
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DR   EMBL; M31628; AAA26757.1; -; Genomic_DNA.
DR   EMBL; AL939111; CAB51444.1; -; Genomic_DNA.
DR   PIR; JQ0638; JQ0638.
DR   RefSeq; NP_626312.1; NC_003888.3.
DR   RefSeq; WP_003976763.1; NZ_VNID01000001.1.
DR   AlphaFoldDB; P16247; -.
DR   SMR; P16247; -.
DR   STRING; 100226.SCO2052; -.
DR   GeneID; 1097486; -.
DR   KEGG; sco:SCO2052; -.
DR   PATRIC; fig|100226.15.peg.2084; -.
DR   eggNOG; COG0131; Bacteria.
DR   HOGENOM; CLU_044308_3_0_11; -.
DR   InParanoid; P16247; -.
DR   OMA; ARHGLFD; -.
DR   PhylomeDB; P16247; -.
DR   UniPathway; UPA00031; UER00011.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004424; F:imidazoleglycerol-phosphate dehydratase activity; IBA:GO_Central.
DR   GO; GO:0000105; P:histidine biosynthetic process; IBA:GO_Central.
DR   CDD; cd07914; IGPD; 1.
DR   Gene3D; 3.30.230.40; -; 2.
DR   HAMAP; MF_00076; HisB; 1.
DR   InterPro; IPR038494; IGPD_sf.
DR   InterPro; IPR000807; ImidazoleglycerolP_deHydtase.
DR   InterPro; IPR020565; ImidazoleglycerP_deHydtase_CS.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   PANTHER; PTHR23133; PTHR23133; 1.
DR   Pfam; PF00475; IGPD; 1.
DR   SUPFAM; SSF54211; SSF54211; 2.
DR   PROSITE; PS00954; IGP_DEHYDRATASE_1; 1.
DR   PROSITE; PS00955; IGP_DEHYDRATASE_2; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Cytoplasm; Histidine biosynthesis; Lyase;
KW   Reference proteome.
FT   CHAIN           1..197
FT                   /note="Imidazoleglycerol-phosphate dehydratase"
FT                   /id="PRO_0000158174"
SQ   SEQUENCE   197 AA;  21589 MW;  65BD875457B47908 CRC64;
     MSRVGRVERT TKETSVLVEI DLDGTGKTDI ATGVGFYDHM LDQLGRHGLF DLTVKTDGDL
     HIDSHHTIED TALALGAAFR QALGDKVGIY RFGNCTVPLD ESLAQVTVDL SGRPYLVHTE
     PENMAPMIGE YDVTMTRHIL ESFVAQAQVA LHVHVPYGRN AHHIVECQFK ALARALRYAS
     ERDPRAAGIL PSTKGAL