ID   HHA_SALTS               Reviewed;          72 AA.
AC   A0A0H3N8G7;
DT   06-JUL-2016, integrated into UniProtKB/Swiss-Prot.
DT   16-SEP-2015, sequence version 1.
DT   03-AUG-2022, entry version 27.
DE   RecName: Full=Hemolysin expression-modulating protein Hha;
GN   Name=hha; OrderedLocusNames=SL1344_0466;
OS   Salmonella typhimurium (strain SL1344).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=216597;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SL1344;
RX   PubMed=22538806; DOI=10.1073/pnas.1201061109;
RA   Kroger C., Dillon S.C., Cameron A.D., Papenfort K., Sivasankaran S.K.,
RA   Hokamp K., Chao Y., Sittka A., Hebrard M., Handler K., Colgan A.,
RA   Leekitcharoenphon P., Langridge G.C., Lohan A.J., Loftus B., Lucchini S.,
RA   Ussery D.W., Dorman C.J., Thomson N.R., Vogel J., Hinton J.C.;
RT   "The transcriptional landscape and small RNAs of Salmonella enterica
RT   serovar Typhimurium.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:E1277-E1286(2012).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=SL1344;
RX   PubMed=17307861; DOI=10.1128/jb.00002-07;
RA   Silphaduang U., Mascarenhas M., Karmali M., Coombes B.K.;
RT   "Repression of intracellular virulence factors in Salmonella by the Hha and
RT   YdgT nucleoid-associated proteins.";
RL   J. Bacteriol. 189:3669-3673(2007).
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=SL1344 / SV5015;
RX   PubMed=19521501; DOI=10.1371/journal.pgen.1000513;
RA   Banos R.C., Vivero A., Aznar S., Garcia J., Pons M., Madrid C., Juarez A.;
RT   "Differential regulation of horizontally acquired and core genome genes by
RT   the bacterial modulator H-NS.";
RL   PLoS Genet. 5:E1000513-E1000513(2009).
CC   -!- FUNCTION: Binds to H-NS and modifies the range of genes it silences; H-
CC       NS alone silences 'core' genes while the H-NS-Hha complex (and
CC       presumably also H-NS-YdgT) silences genes acquired by horizontal gene
CC       transfer (PubMed:19521501). Plays a role silencing virulence factors in
CC       the absence of factors that induce pathogenicity (PubMed:17307861).
CC       Probably requires H-NS to bind DNA (By similarity).
CC       {ECO:0000250|UniProtKB:Q7CR17, ECO:0000269|PubMed:17307861,
CC       ECO:0000305|PubMed:19521501}.
CC   -!- SUBUNIT: Interacts with H-NS (By similarity).
CC       {ECO:0000250|UniProtKB:Q7CR17}.
CC   -!- DISRUPTION PHENOTYPE: Derepression of pathogenicity island 2 (SPI-2)
CC       which is usually repressed in culture; effect is slightly higher in
CC       double hha-ydgT deletions (PubMed:17307861). Double hha-ydgT deletion
CC       mutants lead to deregulation of many genes at least 2-fold, most of
CC       which are also deregulated in an hns deletion, suggesting there are a
CC       large number of hns-regulated genes whose expression is also modulated
CC       by Hha and/or YdgT (PubMed:19521501). Upon infection of C57BL/6 mice a
CC       single hha mutant has 10-100-fold reduced virulence compared to wild-
CC       type, while a double hha-ydgT deletion is 6 orders of magnitude less
CC       virulent (PubMed:17307861). {ECO:0000269|PubMed:17307861,
CC       ECO:0000269|PubMed:19521501}.
CC   -!- SIMILARITY: Belongs to the Hha/YmoA/Cnu family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FQ312003; CBW16567.1; -; Genomic_DNA.
DR   RefSeq; WP_001280991.1; NZ_QASL01000002.1.
DR   AlphaFoldDB; A0A0H3N8G7; -.
DR   SMR; A0A0H3N8G7; -.
DR   EnsemblBacteria; CBW16567; CBW16567; SL1344_0466.
DR   GeneID; 67416465; -.
DR   KEGG; sey:SL1344_0466; -.
DR   PATRIC; fig|216597.6.peg.521; -.
DR   HOGENOM; CLU_190629_0_0_6; -.
DR   OMA; RRCQSID; -.
DR   BioCyc; SENT216597:SL1344_RS02410-MON; -.
DR   Proteomes; UP000008962; Chromosome.
DR   Gene3D; 1.20.1280.40; -; 1.
DR   InterPro; IPR007985; Hemolysn_expr_modulating_HHA.
DR   InterPro; IPR036666; HHA_sf.
DR   Pfam; PF05321; HHA; 1.
DR   SUPFAM; SSF68989; SSF68989; 1.
PE   3: Inferred from homology;
KW   Transcription; Transcription regulation; Virulence.
FT   CHAIN           1..72
FT                   /note="Hemolysin expression-modulating protein Hha"
FT                   /id="PRO_0000436899"
SQ   SEQUENCE   72 AA;  8614 MW;  A63654B87CF1A2FA CRC64;
     MSDKPLTKTD YLMRLRRCQT IDTLERVIEK NKYELSDNEL AVFYSAADHR LAELTMNKLY
     DKIPSSVWKF IR