HEMH2_ORYSJ
ID HEMH2_ORYSJ Reviewed; 526 AA.
AC Q0DIV0; B7EMT8; O22101; Q6L4M5;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Ferrochelatase-2, chloroplastic;
DE EC=4.99.1.1;
DE AltName: Full=Ferrochelatase II;
DE AltName: Full=Heme synthase 2;
DE AltName: Full=Protoheme ferro-lyase 2;
DE Flags: Precursor;
GN OrderedLocusNames=Os05g0361200, LOC_Os05g29760;
GN ORFNames=P0530H10.9, P0692D12.2;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16261349; DOI=10.1007/s00438-005-0039-y;
RA Cheng C.-H., Chung M.C., Liu S.-M., Chen S.-K., Kao F.Y., Lin S.-J.,
RA Hsiao S.-H., Tseng I.C., Hsing Y.-I.C., Wu H.-P., Chen C.-S., Shaw J.-F.,
RA Wu J., Matsumoto T., Sasaki T., Chen H.-C., Chow T.-Y.;
RT "A fine physical map of the rice chromosome 5.";
RL Mol. Genet. Genomics 274:337-345(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
CC -!- FUNCTION: Catalyzes the ferrous insertion into protoporphyrin IX.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+) + heme b = Fe(2+) + protoporphyrin IX;
CC Xref=Rhea:RHEA:22584, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033,
CC ChEBI:CHEBI:57306, ChEBI:CHEBI:60344; EC=4.99.1.1;
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoheme
CC biosynthesis; protoheme from protoporphyrin-IX: step 1/1.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ferrochelatase family. {ECO:0000305}.
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DR EMBL; AC134348; AAT38095.1; -; Genomic_DNA.
DR EMBL; AC135929; AAV31391.1; -; Genomic_DNA.
DR EMBL; AP008211; BAF17223.1; -; Genomic_DNA.
DR EMBL; AP014961; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK073873; BAG93685.1; -; mRNA.
DR RefSeq; XP_015640145.1; XM_015784659.1.
DR AlphaFoldDB; Q0DIV0; -.
DR SMR; Q0DIV0; -.
DR STRING; 4530.OS05T0361200-01; -.
DR PaxDb; Q0DIV0; -.
DR PRIDE; Q0DIV0; -.
DR GeneID; 4338537; -.
DR KEGG; osa:4338537; -.
DR eggNOG; KOG1321; Eukaryota.
DR HOGENOM; CLU_018884_4_3_1; -.
DR InParanoid; Q0DIV0; -.
DR OrthoDB; 1003638at2759; -.
DR BRENDA; 4.99.1.1; 8948.
DR UniPathway; UPA00252; UER00325.
DR Proteomes; UP000000763; Chromosome 5.
DR Proteomes; UP000059680; Chromosome 5.
DR Genevisible; Q0DIV0; OS.
DR GO; GO:0009507; C:chloroplast; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0004325; F:ferrochelatase activity; IBA:GO_Central.
DR GO; GO:0006783; P:heme biosynthetic process; IBA:GO_Central.
DR CDD; cd00419; Ferrochelatase_C; 1.
DR CDD; cd03411; Ferrochelatase_N; 1.
DR HAMAP; MF_00323; Ferrochelatase; 1.
DR InterPro; IPR001015; Ferrochelatase.
DR InterPro; IPR019772; Ferrochelatase_AS.
DR InterPro; IPR033644; Ferrochelatase_C.
DR InterPro; IPR033659; Ferrochelatase_N.
DR PANTHER; PTHR11108; PTHR11108; 1.
DR Pfam; PF00762; Ferrochelatase; 1.
DR TIGRFAMs; TIGR00109; hemH; 1.
DR PROSITE; PS00534; FERROCHELATASE; 1.
PE 2: Evidence at transcript level;
KW Chloroplast; Heme biosynthesis; Iron; Lyase; Plastid;
KW Porphyrin biosynthesis; Reference proteome; Transit peptide.
FT TRANSIT 1..?
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT CHAIN ?..526
FT /note="Ferrochelatase-2, chloroplastic"
FT /id="PRO_0000008884"
SQ SEQUENCE 526 AA; 58590 MW; 95137FEEDA8F3E5F CRC64;
MWSSSQASTR GVIEVGRVEA GPSHFPKRPA PRNSSRVNLS RTYAIKSCSV SSRTGLCLGQ
CYHKKSSACK CKLGWSSQPL SSLRHHLRVH SSASEAVLTS QSDFTKLLVG NEKIGVLLLN
LGGPETLDDV QPFLFNLFAD PDIIRLPRLF RFLQKPLAQF ISVVRAPKSK EGYASIGGGS
PLRQITDAQA EALRKALCDK DIPAKVYVGM RYWHPFTEEA IEQIKRDGIT KLVVLPLYPQ
FSISTSGSSL RLLEGIFRED EYLVNMQHTV IPSWYQREGY IKAMATLIEK ELRTFSEPQK
VMIFFSAHGV PLAYVEEAGD PYKAEMEECV DLIMEELEKR GITNSCTLAY QSRVGPVEWL
RPYTDETIIE LGQKGVKSLL AVPISFVSEH IETLEEIDVE YKELALESGI KHWGRVPALG
CEPTFITDLA DAVIESLPYV GAMAVSNLEA RQPLVPLGSV EELLAAYDSK RDELPPPVTV
WEWGWTKSAE TWNGRAAMLA VLALLVLEVT TGEGFLHQWG ILPLFH
