HEL_HAEIN
ID HEL_HAEIN Reviewed; 274 AA.
AC P26093;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Lipoprotein E;
DE AltName: Full=Outer membrane protein P4;
DE Short=OMP P4;
DE Flags: Precursor;
GN Name=hel; Synonyms=ompP4; OrderedLocusNames=HI_0693;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 263-274.
RC STRAIN=RD / KW20B;
RX PubMed=1715322; DOI=10.1128/iai.59.9.3191-3198.1991;
RA Green B.A., Farley J.E., Quinn-Dey T., Deich R.A., Zlotnick G.W.;
RT "The e (P4) outer membrane protein of Haemophilus influenzae: biologic
RT activity of anti-e serum and cloning and sequencing of the structural
RT gene.";
RL Infect. Immun. 59:3191-3198(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- SUBCELLULAR LOCATION: Cell outer membrane; Lipid-anchor.
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DR EMBL; M68502; AAA51009.1; -; Genomic_DNA.
DR EMBL; L42023; AAC22353.1; -; Genomic_DNA.
DR PIR; B64087; B64087.
DR RefSeq; NP_438853.1; NC_000907.1.
DR RefSeq; WP_010869033.1; NC_000907.1.
DR PDB; 3OCU; X-ray; 1.35 A; A=22-274.
DR PDB; 3OCV; X-ray; 1.55 A; A=22-274.
DR PDB; 3OCW; X-ray; 1.85 A; A=22-274.
DR PDB; 3OCX; X-ray; 1.90 A; A=22-274.
DR PDB; 3OCY; X-ray; 1.40 A; A=22-274.
DR PDB; 3OCZ; X-ray; 1.35 A; A=22-274.
DR PDB; 3SF0; X-ray; 1.35 A; A=22-274.
DR PDBsum; 3OCU; -.
DR PDBsum; 3OCV; -.
DR PDBsum; 3OCW; -.
DR PDBsum; 3OCX; -.
DR PDBsum; 3OCY; -.
DR PDBsum; 3OCZ; -.
DR PDBsum; 3SF0; -.
DR AlphaFoldDB; P26093; -.
DR SMR; P26093; -.
DR STRING; 71421.HI_0693; -.
DR EnsemblBacteria; AAC22353; AAC22353; HI_0693.
DR KEGG; hin:HI_0693; -.
DR PATRIC; fig|71421.8.peg.725; -.
DR eggNOG; COG2503; Bacteria.
DR HOGENOM; CLU_052352_1_0_6; -.
DR OMA; ALNWFQQ; -.
DR PhylomeDB; P26093; -.
DR BioCyc; HINF71421:G1GJ1-728-MON; -.
DR BioCyc; MetaCyc:MON-8381; -.
DR BRENDA; 3.1.3.2; 2529.
DR EvolutionaryTrace; P26093; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR CDD; cd07534; HAD_CAP; 1.
DR Gene3D; 3.40.50.1000; -; 1.
DR InterPro; IPR005519; Acid_phosphat_B-like.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR006423; Lipo_e_P4.
DR Pfam; PF03767; Acid_phosphat_B; 1.
DR PIRSF; PIRSF019271; Acid_Ptase_C; 1.
DR SFLD; SFLDG01125; C1.1:_Acid_Phosphatase_Like; 1.
DR SUPFAM; SSF56784; SSF56784; 1.
DR TIGRFAMs; TIGR01533; lipo_e_P4; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell outer membrane; Direct protein sequencing; Lipoprotein;
KW Membrane; Palmitate; Reference proteome; Signal.
FT SIGNAL 1..20
FT CHAIN 21..274
FT /note="Lipoprotein E"
FT /id="PRO_0000018178"
FT LIPID 21
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000305"
FT LIPID 21
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000305"
FT CONFLICT 30
FT /note="G -> E (in Ref. 1; AAA51009)"
FT /evidence="ECO:0000305"
FT HELIX 30..38
FT /evidence="ECO:0007829|PDB:3OCU"
FT HELIX 41..49
FT /evidence="ECO:0007829|PDB:3OCU"
FT HELIX 51..70
FT /evidence="ECO:0007829|PDB:3OCU"
FT STRAND 78..83
FT /evidence="ECO:0007829|PDB:3OCU"
FT TURN 87..89
FT /evidence="ECO:0007829|PDB:3OCU"
FT HELIX 93..102
FT /evidence="ECO:0007829|PDB:3OCU"
FT HELIX 108..116
FT /evidence="ECO:0007829|PDB:3OCU"
FT HELIX 126..135
FT /evidence="ECO:0007829|PDB:3OCU"
FT STRAND 138..147
FT /evidence="ECO:0007829|PDB:3OCU"
FT TURN 148..151
FT /evidence="ECO:0007829|PDB:3OCU"
FT HELIX 152..162
FT /evidence="ECO:0007829|PDB:3OCU"
FT HELIX 169..171
FT /evidence="ECO:0007829|PDB:3OCU"
FT STRAND 172..177
FT /evidence="ECO:0007829|PDB:3OCU"
FT HELIX 182..190
FT /evidence="ECO:0007829|PDB:3OCU"
FT STRAND 193..202
FT /evidence="ECO:0007829|PDB:3OCU"
FT HELIX 203..206
FT /evidence="ECO:0007829|PDB:3OCU"
FT TURN 209..212
FT /evidence="ECO:0007829|PDB:3OCU"
FT HELIX 215..224
FT /evidence="ECO:0007829|PDB:3OCU"
FT HELIX 225..228
FT /evidence="ECO:0007829|PDB:3OCU"
FT TURN 230..232
FT /evidence="ECO:0007829|PDB:3OCU"
FT STRAND 233..235
FT /evidence="ECO:0007829|PDB:3OCU"
FT STRAND 239..242
FT /evidence="ECO:0007829|PDB:3OCZ"
FT HELIX 243..246
FT /evidence="ECO:0007829|PDB:3OCU"
FT HELIX 252..254
FT /evidence="ECO:0007829|PDB:3OCU"
FT HELIX 257..267
FT /evidence="ECO:0007829|PDB:3OCU"
SQ SEQUENCE 274 AA; 30431 MW; 047C693194155E6B CRC64;
MKTTLKMTAL AALSAFVLAG CGSHQMKSEG HANMQLQQQA VLGLNWMQDS GEYKALAYQA
YNAAKVAFDH AKVAKGKKKA VVADLDETML DNSPYAGWQV QNNKPFDGKD WTRWVDARQS
RAVPGAVEFN NYVNSHNGKV FYVTNRKDST EKSGTIDDMK RLGFNGVEES AFYLKKDKSA
KAARFAEIEK QGYEIVLYVG DNLDDFGNTV YGKLNADRRA FVDQNQGKFG KTFIMLPNAN
YGGWEGGLAE GYFKKDTQGQ IKARLDAVQA WDGK
