HBG_RABIT
ID HBG_RABIT Reviewed; 147 AA.
AC P02099;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Hemoglobin subunit gamma;
DE AltName: Full=Gamma-globin;
DE AltName: Full=Hemoglobin beta-3;
DE AltName: Full=Hemoglobin gamma chain;
GN Name=HBG;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=6271761; DOI=10.1016/s0021-9258(19)68473-5;
RA Hardison R.C.;
RT "The nucleotide sequence of rabbit embryonic globin gene beta 3.";
RL J. Biol. Chem. 256:11780-11786(1981).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=2486295; DOI=10.1016/0022-2836(89)90362-8;
RA Margot J.B., Demers G.W., Hardison R.C.;
RT "Complete nucleotide sequence of the rabbit beta-like globin gene cluster.
RT Analysis of intergenic sequences and comparison with the human beta-like
RT globin gene cluster.";
RL J. Mol. Biol. 205:15-40(1989).
CC -!- FUNCTION: This protein functions as an embryonic globin, but the gene
CC structure and chromosomal location resemble more closely the human
CC gamma chain gene, which codes for a fetal globin.
CC -!- SUBUNIT: Heterotetramer of two alpha chains and two gamma chains.
CC -!- TISSUE SPECIFICITY: Red blood cells.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR EMBL; M18818; AAA02984.1; -; Unassigned_DNA.
DR EMBL; V00883; CAA24252.1; -; Genomic_DNA.
DR PIR; A02417; HBRB3.
DR RefSeq; NP_001164974.1; NM_001171503.1.
DR AlphaFoldDB; P02099; -.
DR SMR; P02099; -.
DR STRING; 9986.ENSOCUP00000017035; -.
DR GeneID; 100328858; -.
DR KEGG; ocu:100328858; -.
DR CTD; 3048; -.
DR eggNOG; KOG3378; Eukaryota.
DR HOGENOM; CLU_003827_10_0_1; -.
DR InParanoid; P02099; -.
DR OMA; SADAIMH; -.
DR OrthoDB; 1370439at2759; -.
DR TreeFam; TF333268; -.
DR Proteomes; UP000001811; Unplaced.
DR ExpressionAtlas; P02099; baseline.
DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR CDD; cd08925; Hb-beta-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002337; Hemoglobin_b.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00814; BETAHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 2: Evidence at transcript level;
KW Heme; Iron; Metal-binding; Oxygen transport; Reference proteome; Transport.
FT CHAIN 1..147
FT /note="Hemoglobin subunit gamma"
FT /id="PRO_0000053267"
FT BINDING 64
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT BINDING 93
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
SQ SEQUENCE 147 AA; 16225 MW; A259C679F76C1D82 CRC64;
MVHFTAEEKA AITSTWKLVD VEDAGAEALG RLLVVYPWTQ RFFDSFGNLS SSSAIMGNPK
VKAHGKKVLT AFGDAVKNVD DLKNTFAHLS ELHCDRLHVD PENFKLLGNV LVIVLAKYFG
KEFTPQVQSA WQKLVAGVAT ALAHKYH
