HBE_NOTEU
ID HBE_NOTEU Reviewed; 147 AA.
AC P81042; Q6H1U8;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Hemoglobin subunit epsilon;
DE AltName: Full=Epsilon-globin;
DE AltName: Full=Hemoglobin epsilon chain;
GN Name=HBE1;
OS Notamacropus eugenii (Tammar wallaby) (Macropus eugenii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Diprotodontia; Macropodidae; Notamacropus.
OX NCBI_TaxID=9315;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Liver;
RX PubMed=15461421; DOI=10.1007/s00239-004-2584-0;
RA Wheeler D., Hope R.M., Cooper S.J.B., Gooley A.A., Holland R.A.B.;
RT "Linkage of the beta-like omega-globin gene to alpha-like globin genes in
RT an Australian marsupial supports the chromosome duplication model for
RT separation of globin gene clusters.";
RL J. Mol. Evol. 58:642-652(2004).
RN [2]
RP PROTEIN SEQUENCE OF 2-61.
RC TISSUE=Blood;
RX PubMed=9342240; DOI=10.1111/j.1432-1033.1997.00864.x;
RA Holland R.A.B., Gooley A.A.;
RT "Characterization of the embryonic globin chains of the marsupial Tammar
RT wallaby, Macropus eugenii.";
RL Eur. J. Biochem. 248:864-871(1997).
CC -!- FUNCTION: Hemoglobin epsilon chain is an embryonic-type beta-type chain
CC found in prenatal and neonatal marsupials.
CC -!- TISSUE SPECIFICITY: Red blood cells.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR EMBL; AY450927; AAS15709.1; -; Genomic_DNA.
DR AlphaFoldDB; P81042; -.
DR SMR; P81042; -.
DR Ensembl; ENSMEUT00000000693; ENSMEUP00000000639; ENSMEUG00000000695.
DR HOGENOM; CLU_003827_10_0_1; -.
DR OMA; INGLWSK; -.
DR TreeFam; TF333268; -.
DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR CDD; cd08925; Hb-beta-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002337; Hemoglobin_b.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00814; BETAHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW Phosphoprotein; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:9342240"
FT CHAIN 2..147
FT /note="Hemoglobin subunit epsilon"
FT /id="PRO_0000053216"
FT BINDING 64
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT BINDING 93
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT MOD_RES 14
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02100"
FT MOD_RES 51
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02100"
FT CONFLICT 53
FT /note="S -> A (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 147 AA; 16076 MW; 626CDD45F0600A45 CRC64;
MVHFTAEEKT AITSVWGKVN VEETGGEALG RLLVVYPWTQ RFFDSFGNLS SASAILGNPK
VKAHGKKVLT SLGEAVKNLD NLKATFSKLS ELHCDKLHVD PENFRLLGNV LVVVLAVHFG
KEFTPEVHAA WQKLVAGVAS ALAHKYH
