HBA3_XENTR
ID HBA3_XENTR Reviewed; 142 AA.
AC P08422; A4IGS6; Q38IV8;
DT 01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Hemoglobin subunit alpha-3;
DE AltName: Full=Alpha-3-globin;
DE AltName: Full=Alpha-globin larval 8;
DE AltName: Full=Hemoglobin alpha-3 chain;
DE AltName: Full=Larval alpha globin;
GN Name=hba-l8; ORFNames=TTpA002j01.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3347501; DOI=10.1093/nar/16.4.1625;
RA Knoechel W., Pfanne K., Beck J., Meyerhof W.;
RT "Nucleotide sequence of a larval alpha globin gene from Xenopus
RT tropicalis.";
RL Nucleic Acids Res. 16:1625-1625(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Roche D.D., Cheng J.F., Harland R.M.;
RT "Characterization of alpha globin genes in Xenopus tropicalis.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tadpole;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This is a larval (tadpole) alpha-globin.
CC -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC -!- TISSUE SPECIFICITY: Red blood cells.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR EMBL; X06664; CAA29864.1; -; Genomic_DNA.
DR EMBL; DQ224418; ABB04105.1; -; Genomic_DNA.
DR EMBL; CR926438; CAJ82936.1; -; mRNA.
DR EMBL; BC135231; AAI35232.1; -; mRNA.
DR PIR; A28538; A28538.
DR RefSeq; NP_001015904.1; NM_001015904.2.
DR AlphaFoldDB; P08422; -.
DR SMR; P08422; -.
DR STRING; 8364.ENSXETP00000002492; -.
DR PaxDb; P08422; -.
DR DNASU; 548658; -.
DR Ensembl; ENSXETT00000002492; ENSXETP00000002492; ENSXETG00000025663.
DR GeneID; 548658; -.
DR KEGG; xtr:548658; -.
DR CTD; 548658; -.
DR Xenbase; XB-GENE-973870; hba3.
DR eggNOG; KOG3378; Eukaryota.
DR HOGENOM; CLU_003827_10_2_1; -.
DR InParanoid; P08422; -.
DR OMA; VTIWAKV; -.
DR OrthoDB; 1398217at2759; -.
DR PhylomeDB; P08422; -.
DR TreeFam; TF332328; -.
DR Proteomes; UP000008143; Chromosome 9.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000025663; Expressed in liver and 15 other tissues.
DR ExpressionAtlas; P08422; differential.
DR GO; GO:0031838; C:haptoglobin-hemoglobin complex; IBA:GO_Central.
DR GO; GO:0005833; C:hemoglobin complex; IBA:GO_Central.
DR GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0043177; F:organic acid binding; IBA:GO_Central.
DR GO; GO:0019825; F:oxygen binding; IBA:GO_Central.
DR GO; GO:0005344; F:oxygen carrier activity; IBA:GO_Central.
DR GO; GO:0098869; P:cellular oxidant detoxification; IEA:GOC.
DR GO; GO:0042744; P:hydrogen peroxide catabolic process; IBA:GO_Central.
DR CDD; cd08927; Hb-alpha-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002338; Hemoglobin_a-typ.
DR InterPro; IPR002339; Hemoglobin_pi.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00612; ALPHAHAEM.
DR PRINTS; PR00815; PIHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 2: Evidence at transcript level;
KW Heme; Iron; Metal-binding; Oxygen transport; Reference proteome; Transport.
FT INIT_MET 1
FT /note="Removed"
FT CHAIN 2..142
FT /note="Hemoglobin subunit alpha-3"
FT /id="PRO_0000052813"
FT BINDING 59
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT BINDING 88
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
SQ SEQUENCE 142 AA; 15486 MW; 20F7C986886274B5 CRC64;
MTLTDSEKAA VVALWSKIAP QASAIGAEAL ERLFLSYPQT KTYFSHFDVS HGSADLQNHG
GKVVNALGEA AKHLNDLDAA LSTLSDLHAY NLRVDPGNFK LLSHTIQVTL AVHFQKEFDA
ATQAAWDKFL SEVATVLTSK YR
