ID   HBA2_TELPE              Reviewed;         137 AA.
AC   P83113;
DT   28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2003, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Hemoglobin subunit alpha-2;
DE   AltName: Full=Alpha-2-globin;
DE   AltName: Full=Hemoglobin alpha-2 chain;
DE   Flags: Fragment;
OS   Telmatobius peruvianus (Andean frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Ceratophryidae; Telmatobiinae;
OC   Telmatobius.
OX   NCBI_TaxID=170953 {ECO:0000305};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE.
RX   PubMed=12376398; DOI=10.1152/ajpregu.00292.2002;
RA   Weber R.E., Ostojic H., Fago A., Dewilde S., Van Hauwaert M.-L., Moens L.,
RA   Monge C.;
RT   "Novel mechanism for high-altitude adaptation in hemoglobin of the Andean
RT   frog Telmatobius peruvianus.";
RL   Am. J. Physiol. 283:R1052-R1060(2002).
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- PTM: The N-terminus of the mature protein is acetylated.
CC       {ECO:0000269|PubMed:12376398}.
CC   -!- SIMILARITY: Belongs to the globin family.
CC       {ECO:0000250|UniProtKB:P01966, ECO:0000255|PROSITE-ProRule:PRU00238}.
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DR   AlphaFoldDB; P83113; -.
DR   SMR; P83113; -.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08927; Hb-alpha-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002338; Hemoglobin_a-typ.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00612; ALPHAHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Direct protein sequencing; Heme; Iron; Metal-binding;
KW   Oxygen transport; Transport.
FT   CHAIN           <1..137
FT                   /note="Hemoglobin subunit alpha-2"
FT                   /id="PRO_0000052781"
FT   BINDING         54
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT   BINDING         83
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT   NON_TER         1
FT                   /evidence="ECO:0000303|PubMed:12376398"
SQ   SEQUENCE   137 AA;  15294 MW;  31D7D2E8C595B37A CRC64;
     DDRSHILAIW PSVASHGADY GGEALYRLFL SNPQTKTYFP NFDFHKDSPQ IKAHGKKVVD
     ALTEASKHLD NINGALSKLF DLHAFELRVD PGNFPLLAHH INVTIAVMFP DDKFDIAHHQ
     LDKFLAAVGG SLTSKYR