ID   HBA2_OTOCR              Reviewed;         142 AA.
AC   P01939;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Hemoglobin subunit alpha-B;
DE   AltName: Full=Alpha-B-globin;
DE   AltName: Full=Alpha-II;
DE   AltName: Full=Hemoglobin alpha-B chain;
GN   Name=HBAB;
OS   Otolemur crassicaudatus (Brown greater galago) (Galago crassicaudatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC   Galagidae; Otolemur.
OX   NCBI_TaxID=9463;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3586010; DOI=10.1016/0022-2836(86)90022-7;
RA   Sawada I., Schmid C.W.;
RT   "Primate evolution of the alpha-globin gene cluster and its Alu-like
RT   repeats.";
RL   J. Mol. Biol. 192:693-709(1986).
RN   [2]
RP   PROTEIN SEQUENCE OF 2-142.
RX   PubMed=4005042; DOI=10.1515/bchm3.1985.366.1.265;
RA   Watanabe B., Fujii T., Nakashima Y., Maita T., Matsuda G.;
RT   "Amino-acid sequences of the alpha and beta chains of adult hemoglobins of
RT   the Grand Galago, Galago crassicaudatus.";
RL   Biol. Chem. Hoppe-Seyler 366:265-269(1985).
CC   -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC       peripheral tissues.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   EMBL; M29648; AAA35449.1; -; Genomic_DNA.
DR   PIR; A02261; HAGC.
DR   PIR; A25597; A25597.
DR   PIR; B25597; B25597.
DR   AlphaFoldDB; P01939; -.
DR   SMR; P01939; -.
DR   PRIDE; P01939; -.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08927; Hb-alpha-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002338; Hemoglobin_a-typ.
DR   InterPro; IPR002339; Hemoglobin_pi.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00612; ALPHAHAEM.
DR   PRINTS; PR00815; PIHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW   Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:4005042"
FT   CHAIN           2..142
FT                   /note="Hemoglobin subunit alpha-B"
FT                   /id="PRO_0000052639"
FT   BINDING         59
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         88
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT   CONFLICT        20
FT                   /note="A -> G (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        54
FT                   /note="T -> A (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        72
FT                   /note="L -> S (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        103
FT                   /note="R -> S (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        118
FT                   /note="F -> L (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        126
FT                   /note="L -> F (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   142 AA;  15520 MW;  5F1FF1A83E4868CA CRC64;
     MVLSPTDKSN VKAAWEKVGA HAGDYGAEAL ERMFLSFPTT KTYFPHFDLS HGSTQVKGHG
     KKVADALTNA VLHVDDMPSA LSALSDLHAH KLRVDPVNFK LLRHCLLVTL ACHHPAEFTP
     AVHASLDKFM ASVSTVLTSK YR