ID   HBA1_TACAC              Reviewed;         141 AA.
AC   P01977;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Hemoglobin subunit alpha-1;
DE   AltName: Full=Alpha-1-globin;
DE   AltName: Full=Hemoglobin alpha-1 chain;
OS   Tachyglossus aculeatus aculeatus (Southeast Australian short-beaked
OS   echidna).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Monotremata; Tachyglossidae; Tachyglossus.
OX   NCBI_TaxID=49271;
RN   [1]
RP   PROTEIN SEQUENCE (VARIANT B).
RX   PubMed=4748330; DOI=10.1071/bi9730877;
RA   Whittaker R.G., Fisher W.K., Thompson E.O.P.;
RT   "Studies on monotreme proteins. II. Amino acid sequence of the alpha-chain
RT   in haemoglobin from the echidna, Tachyglossus aculeatus aculeatus.";
RL   Aust. J. Biol. Sci. 26:877-888(1973).
RN   [2]
RP   PROTEIN SEQUENCE (VARIANT A).
RX   PubMed=4415942; DOI=10.1071/bi9740111;
RA   Dodgson S.J., Fisher W.K., Thompson E.O.P.;
RT   "Studies on monotreme proteins. IV. Amino acid sequence of haemoglobin-IA
RT   of the echidna; a comparison of major haemoglobins from two geographical
RT   groups of echidnas.";
RL   Aust. J. Biol. Sci. 27:111-115(1974).
CC   -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC       peripheral tissues.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- MISCELLANEOUS: Echidnas have a major hemoglobin I (with alpha-1 chain
CC       variants A, B, and C) and a minor hemoglobin II (with alpha-2 chain
CC       variants A and B). All hemoglobins may have the same beta chain. The
CC       sequences of both alpha-1 A and B variants differ from that of the
CC       alpha-2 A variant at nine positions.
CC   -!- MISCELLANEOUS: The sequence shown is that of alpha-1 B.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   PIR; A90089; HATG.
DR   AlphaFoldDB; P01977; -.
DR   SMR; P01977; -.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08927; Hb-alpha-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002338; Hemoglobin_a-typ.
DR   InterPro; IPR002339; Hemoglobin_pi.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00612; ALPHAHAEM.
DR   PRINTS; PR00815; PIHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW   Transport.
FT   CHAIN           1..141
FT                   /note="Hemoglobin subunit alpha-1"
FT                   /id="PRO_0000052773"
FT   BINDING         58
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         87
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT   VARIANT         12
FT                   /note="S -> G (in alpha-1 A variant)"
FT   VARIANT         78
FT                   /note="S -> N (in alpha-1 A variant)"
FT   VARIANT         102
FT                   /note="A -> S (in alpha-1 A variant)"
FT   VARIANT         115
FT                   /note="A -> E (in alpha-1 A variant)"
SQ   SEQUENCE   141 AA;  15462 MW;  D8D0FF702686A0F6 CRC64;
     VLTDAEKKEV TSLWGKASGH AEEYGAEALE RLFLSFPTTK TYFSHMDLSK GSAQVKAHGK
     RVADALTTAA GHFNDMDSAL SALSDLHAHK LRVDPVNFKL LAHCFLVVLA RHHPAEFTPS
     AHAAMDKFLS RVATVLTSKY R