HBA1_SCHPO
ID HBA1_SCHPO Reviewed; 399 AA.
AC Q09146; Q9UU29;
DT 29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Brefeldin A resistance protein;
DE AltName: Full=Caffeine resistance protein 1;
GN Name=hba1; Synonyms=caf1; ORFNames=SPBC365.13c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, AND
RP PHOSPHORYLATION.
RC STRAIN=BAP1;
RX PubMed=8621569; DOI=10.1074/jbc.271.15.9166;
RA Turi T.G., Mueller U.W., Sazer S., Rose J.K.;
RT "Characterization of a nuclear protein conferring brefeldin A resistance in
RT Schizosaccharomyces pombe.";
RL J. Biol. Chem. 271:9166-9171(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9894913; DOI=10.1007/s004380050914;
RA Benko Z., Sipiczki M., Carr A.M.;
RT "Cloning of caf1+, caf2+ and caf4+ from Schizosaccharomyces pombe: their
RT involvement in multidrug resistance, UV and pH sensitivity.";
RL Mol. Gen. Genet. 260:434-443(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 152-359.
RC STRAIN=ATCC 38364 / 968;
RX PubMed=10759889; DOI=10.1046/j.1365-2443.2000.00317.x;
RA Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T.,
RA Hiraoka Y.;
RT "Large-scale screening of intracellular protein localization in living
RT fission yeast cells by the use of a GFP-fusion genomic DNA library.";
RL Genes Cells 5:169-190(2000).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8621569}.
CC -!- PTM: Phosphorylated. {ECO:0000269|PubMed:8621569}.
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DR EMBL; U38783; AAC49261.1; -; Genomic_DNA.
DR EMBL; CU329671; CAB44765.1; -; Genomic_DNA.
DR EMBL; AB027850; BAA87154.1; -; Genomic_DNA.
DR PIR; T40320; T40320.
DR RefSeq; NP_596042.1; NM_001021952.2.
DR AlphaFoldDB; Q09146; -.
DR SMR; Q09146; -.
DR BioGRID; 277464; 5.
DR STRING; 4896.SPBC365.13c.1; -.
DR iPTMnet; Q09146; -.
DR MaxQB; Q09146; -.
DR PaxDb; Q09146; -.
DR PRIDE; Q09146; -.
DR EnsemblFungi; SPBC365.13c.1; SPBC365.13c.1:pep; SPBC365.13c.
DR PomBase; SPBC365.13c; hba1.
DR VEuPathDB; FungiDB:SPBC365.13c; -.
DR eggNOG; KOG0864; Eukaryota.
DR HOGENOM; CLU_057901_0_0_1; -.
DR InParanoid; Q09146; -.
DR OMA; CMNSIDE; -.
DR PRO; PR:Q09146; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; IDA:PomBase.
DR GO; GO:0031267; F:small GTPase binding; ISM:PomBase.
DR GO; GO:0006611; P:protein export from nucleus; IMP:PomBase.
DR GO; GO:0050790; P:regulation of catalytic activity; IEA:GOC.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000156; Ran_bind_dom.
DR InterPro; IPR045255; RanBP1-like.
DR PANTHER; PTHR23138; PTHR23138; 1.
DR Pfam; PF00638; Ran_BP1; 1.
DR SMART; SM00160; RanBD; 1.
DR PROSITE; PS50196; RANBD1; 1.
PE 1: Evidence at protein level;
KW Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..399
FT /note="Brefeldin A resistance protein"
FT /id="PRO_0000213673"
FT DOMAIN 256..396
FT /note="RanBD1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00164"
FT REGION 1..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..73
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..126
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..219
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..254
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 399 AA; 43201 MW; 52F5A03F0020ACEE CRC64;
MTSKMENNKD ESISTKNALE EKSNETKDET SKRKHDPAEE ESAVSTKVSK SEPLEDKGNA
EVKEFKETTK SNGVKPEVEI TESTKIQKES NTEPCISTGG KVEEKELKVN KDVDENEGHV
AVETGKKESA AKPAASVSPF SQFASFSNAS SPFSNVSTAS SEPKEEKSAF GAFASSKSAF
TMKSVKDSPF KKFAAGTAVE TESGSGKEKE NDKKSSENFD ELLANTSAKA FENQKGSAGE
TKSEPKEADK GSGDSTKSTM HQLSDSEIIT GEEEEESIFS VRARLYVVAD EKKTWKERGQ
GILKVNVPKQ RGSGSGRLLM RNDAVHRVIM NVPLFQGMSK KSLQIASASS GGSANYLKIF
VIENGKSVLY AVRVKDNSLA EQLRNHVLEA IPKGGREDA
