ID   HB2A_RAT                Reviewed;         233 AA.
AC   P06341;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1988, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Rano class II histocompatibility antigen, A beta chain;
DE   AltName: Full=RT1 class II histocompatibility antigen, A beta chain;
DE   Flags: Fragment;
GN   Name=RT1-B;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3865896; DOI=10.1007/bf00430314;
RA   Eccles S.J., McMaster W.R.;
RT   "DNA sequence analysis of a rat RT1 class II A beta gene.";
RL   Immunogenetics 22:653-663(1985).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the MHC class II family. {ECO:0000305}.
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DR   EMBL; M15358; AAA74477.1; -; Genomic_DNA.
DR   EMBL; M15354; AAA74477.1; JOINED; Genomic_DNA.
DR   EMBL; M15355; AAA74477.1; JOINED; Genomic_DNA.
DR   EMBL; M15356; AAA74477.1; JOINED; Genomic_DNA.
DR   EMBL; M15357; AAA74477.1; JOINED; Genomic_DNA.
DR   PIR; A02235; HLRTAB.
DR   AlphaFoldDB; P06341; -.
DR   SMR; P06341; -.
DR   GlyGen; P06341; 1 site.
DR   PhosphoSitePlus; P06341; -.
DR   PRIDE; P06341; -.
DR   RGD; 3467; RT1-B.
DR   InParanoid; P06341; -.
DR   PhylomeDB; P06341; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042613; C:MHC class II protein complex; IBA:GO_Central.
DR   GO; GO:0023026; F:MHC class II protein complex binding; IBA:GO_Central.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IBA:GO_Central.
DR   GO; GO:0002503; P:peptide antigen assembly with MHC class II protein complex; IBA:GO_Central.
DR   GO; GO:0050870; P:positive regulation of T cell activation; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 3.10.320.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR014745; MHC_II_a/b_N.
DR   InterPro; IPR000353; MHC_II_b_N.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00969; MHC_II_beta; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SMART; SM00921; MHC_II_beta; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   SUPFAM; SSF54452; SSF54452; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   3: Inferred from homology;
KW   Adaptive immunity; Glycoprotein; Immunity; Membrane; MHC II;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           <1..233
FT                   /note="Rano class II histocompatibility antigen, A beta
FT                   chain"
FT                   /id="PRO_0000080755"
FT   TOPO_DOM        <1..194
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        216..233
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          93..181
FT                   /note="Ig-like C1-type"
FT   REGION          <1..80
FT                   /note="Beta-1"
FT   REGION          81..184
FT                   /note="Beta-2"
FT   REGION          185..194
FT                   /note="Connecting peptide"
FT   CARBOHYD        14
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
SQ   SEQUENCE   233 AA;  26827 MW;  293922C66A768E75 CRC64;
     DFVYQFKGLC YYTNGTQRIR SVDRRFYNQE EFLRYDSDVG EFRALTELGR SWADDWNSQK
     EILEQKRAEM DTVCRYNYEE TEVPTSLRRL ERPNVAISLS RTEALNHHNL LVCSVTDFYP
     AQIKVRWFRN GQEETTGVVS TQLIKNGDWT FQILVMLEMT PQRGDVYTCH VDHASLESPV
     TVEWRAQSES AQSKMLSGIG GLVLGVIFLG LGLFIRHKRQ KGPQGPPPAG LLQ