ID   HAUS8_XENLA             Reviewed;         367 AA.
AC   Q0IHJ3;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=HAUS augmin-like complex subunit 8;
DE   AltName: Full=HEC1/NDC80-interacting centrosome-associated protein 1;
DE   AltName: Full=Sarcoma antigen NY-SAR-48 homolog;
GN   Name=haus8; Synonyms=hice1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Contributes to mitotic spindle assembly, maintenance of
CC       centrosome integrity and completion of cytokinesis as part of the HAUS
CC       augmin-like complex. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the HAUS augmin-like complex. The complex
CC       interacts with the gamma-tubulin ring complex and this interaction is
CC       required for spindle assembly. Associates with microtubules. The
CC       interaction with microtubules is strong during mitosis, while it is
CC       weak or absent during interphase. It is unclear whether this
CC       interaction is direct or indirect (By similarity).
CC       {ECO:0000250|UniProtKB:Q9BT25}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BT25}.
CC       Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC       {ECO:0000250|UniProtKB:Q9BT25}. Cytoplasm, cytoskeleton, spindle
CC       {ECO:0000250|UniProtKB:Q9BT25}. Cytoplasm, cytoskeleton, spindle pole
CC       {ECO:0000250|UniProtKB:Q9BT25}. Note=During interphase, primarily
CC       cytoplasmic and associates with centrosomes and with the mitotic
CC       spindles, preferentially at the spindle pole vicinity. During anaphase
CC       and telophase, additionally associates with the spindle midzone and
CC       midbody, respectively. Localizes to mitotic spindle microtubules (By
CC       similarity). {ECO:0000250|UniProtKB:Q9BT25}.
CC   -!- SIMILARITY: Belongs to the HAUS8 family. {ECO:0000305}.
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DR   EMBL; BC123131; AAI23132.1; -; mRNA.
DR   RefSeq; NP_001090302.1; NM_001096833.1.
DR   AlphaFoldDB; Q0IHJ3; -.
DR   SMR; Q0IHJ3; -.
DR   DNASU; 779211; -.
DR   GeneID; 779211; -.
DR   KEGG; xla:779211; -.
DR   CTD; 779211; -.
DR   Xenbase; XB-GENE-5797188; haus8.L.
DR   OrthoDB; 809178at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 779211; Expressed in oocyte and 16 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070652; C:HAUS complex; ISS:UniProtKB.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:1990498; C:mitotic spindle microtubule; ISS:UniProtKB.
DR   GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007098; P:centrosome cycle; ISS:UniProtKB.
DR   GO; GO:0051225; P:spindle assembly; ISS:UniProtKB.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Microtubule; Mitosis; Reference proteome.
FT   CHAIN           1..367
FT                   /note="HAUS augmin-like complex subunit 8"
FT                   /id="PRO_0000319940"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          54..81
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          183..221
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        9..23
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   367 AA;  41084 MW;  7A080D3D3EAFBD87 CRC64;
     MSEAGVAPIE DGSQNSSGGS SGDAALKKSK GGAKVVKSRY MQIGRSKVSK NSLANTTVCS
     GGKVPERGSG GTPTRRSLAP HKAKITAAVP LPALDGSIFT KEDLQSTLLD GHRIARPDLD
     LSVINDRTLQ KITPRPVVTS EQKKPKRDTT PVNLVPEDMV EMIESQTLLL TYLTIKMQKN
     LFRLEEKAER NLLLVNDQKD QLQETIHMMK RDLTLLQREE RLRDLIEKQD EVLTPVVTSK
     DPFKDNYTTF ATALDSTRHQ LAIKNIHITG NRHRYLEELQ KHLAITKSLL EEIMPSHASE
     NAESFDTIKD LENIVLKTDE ELARSFRQIL DLSFKVNKEI SLQSQKAVEE TCESALVRQW
     YFDGSLP