HAT3_ARATH
ID HAT3_ARATH Reviewed; 315 AA.
AC P46602; Q546G9; Q9M220;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2001, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Homeobox-leucine zipper protein HAT3;
DE AltName: Full=Homeodomain-leucine zipper protein HAT3;
DE Short=HD-ZIP protein 3;
GN Name=HAT3; OrderedLocusNames=At3g60390; ORFNames=T8B10_50;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=7915839; DOI=10.1073/pnas.91.18.8393;
RA Schena M., Davis R.W.;
RT "Structure of homeobox-leucine zipper genes suggests a model for the
RT evolution of gene families.";
RL Proc. Natl. Acad. Sci. U.S.A. 91:8393-8397(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Carabelli M., Ciarbelli A.R., Ruzza V., Sessa G., Steindler C., Ruberti I.;
RT "Nucleotide sequence of the Arabidopsis HAT3 mRNA, encoding an HD-Zip II
RT protein related to ATHB-2.";
RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [6]
RP GENE FAMILY.
RX PubMed=16055682; DOI=10.1104/pp.105.063461;
RA Henriksson E., Olsson A.S.B., Johannesson H., Johansson H., Hanson J.,
RA Engstroem P., Soederman E.;
RT "Homeodomain leucine zipper class I genes in Arabidopsis. Expression
RT patterns and phylogenetic relationships.";
RL Plant Physiol. 139:509-518(2005).
CC -!- FUNCTION: Probable transcription factor. {ECO:0000250}.
CC -!- INTERACTION:
CC P46602; O04292: ATHB-9; NbExp=5; IntAct=EBI-4450405, EBI-1536772;
CC P46602; Q8GXM7: ATHB-X; NbExp=5; IntAct=EBI-4450405, EBI-3133795;
CC P46602; P46600: HAT1; NbExp=5; IntAct=EBI-4450405, EBI-15195911;
CC P46602; P46601: HAT2; NbExp=3; IntAct=EBI-4450405, EBI-4448195;
CC P46602; P46604: HAT22; NbExp=3; IntAct=EBI-4450405, EBI-4448318;
CC P46602; Q05466: HAT4; NbExp=3; IntAct=EBI-4450405, EBI-4428728;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the HD-ZIP homeobox family. Class II subfamily.
CC {ECO:0000305}.
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DR EMBL; U09338; AAA56904.1; -; mRNA.
DR EMBL; U09339; AAA56905.1; -; Genomic_DNA.
DR EMBL; AJ440781; CAD29465.1; -; mRNA.
DR EMBL; AL138646; CAB81825.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE80054.1; -; Genomic_DNA.
DR EMBL; AY099565; AAM20417.1; -; mRNA.
DR EMBL; BT008713; AAP42726.1; -; mRNA.
DR PIR; T47850; T47850.
DR PIR; T52350; T52350.
DR RefSeq; NP_191598.1; NM_115903.3.
DR AlphaFoldDB; P46602; -.
DR SMR; P46602; -.
DR BioGRID; 10524; 16.
DR IntAct; P46602; 15.
DR STRING; 3702.AT3G60390.1; -.
DR PaxDb; P46602; -.
DR PRIDE; P46602; -.
DR ProteomicsDB; 230307; -.
DR EnsemblPlants; AT3G60390.1; AT3G60390.1; AT3G60390.
DR GeneID; 825210; -.
DR Gramene; AT3G60390.1; AT3G60390.1; AT3G60390.
DR KEGG; ath:AT3G60390; -.
DR Araport; AT3G60390; -.
DR TAIR; locus:2103396; AT3G60390.
DR eggNOG; KOG0483; Eukaryota.
DR HOGENOM; CLU_049516_2_0_1; -.
DR InParanoid; P46602; -.
DR OMA; SHMHMQS; -.
DR OrthoDB; 1388148at2759; -.
DR PhylomeDB; P46602; -.
DR PRO; PR:P46602; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; P46602; baseline and differential.
DR Genevisible; P46602; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR006712; HD-ZIP_N.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003106; Leu_zip_homeo.
DR Pfam; PF02183; HALZ; 1.
DR Pfam; PF04618; HD-ZIP_N; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00340; HALZ; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..315
FT /note="Homeobox-leucine zipper protein HAT3"
FT /id="PRO_0000048900"
FT DNA_BIND 159..218
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 140..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..247
FT /note="Leucine-zipper"
FT REGION 280..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..297
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 212
FT /note="A -> Q (in Ref. 1; AAA56904/AAA56905)"
FT /evidence="ECO:0000305"
FT CONFLICT 281
FT /note="S -> P (in Ref. 1; AAA56904/AAA56905)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 315 AA; 34747 MW; FDD35A6405CF9F01 CRC64;
MSERDDGLGL SLSLSLGFNQ KDPSSRLNPM PLASYASSSH MQHMQQSNYN HPQKIQNTWI
NMFQSSERNS DMRSFLRGID VNRAPSTVVV DVEDEGAGVS SPNSTVSSVM SGKKSERELM
AAAGAVGGGR VEDNEIERAS CSLGGGSDDE DGSGNGDDSS RKKLRLSKEQ ALVLEETFKE
HSTLNPKQKM ALAKQLNLRT RQVEVWFQNR RARTKLKQTE VDCEYLKRCC ENLTDENRRL
QKEVSELRAL KLSPHLYMHM KPPTTLTMCP SCERVAVTSS SSSVAPPVMN SSSPMGPMSP
WAAMPLRQRP AAGSH
