ID   HAT2_YARLI              Reviewed;         452 AA.
AC   Q6C7Q4;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Histone acetyltransferase type B subunit 2;
GN   Name=HAT2; OrderedLocusNames=YALI0D26279g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Regulatory subunit of the histone acetylase B (HAT-B)
CC       complex. The complex acetylates 'Lys-12' of histone H4 which is
CC       required for telomeric silencing (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the HAT-B complex composed of at least HAT1 and
CC       HAT2. The HAT-B complex binds to histone H4 tail (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
CC       {ECO:0000305}.
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DR   EMBL; CR382130; CAG81514.1; -; Genomic_DNA.
DR   RefSeq; XP_503308.1; XM_503308.1.
DR   AlphaFoldDB; Q6C7Q4; -.
DR   SMR; Q6C7Q4; -.
DR   STRING; 4952.CAG81514; -.
DR   EnsemblFungi; CAG81514; CAG81514; YALI0_D26279g.
DR   GeneID; 2910744; -.
DR   KEGG; yli:YALI0D26279g; -.
DR   VEuPathDB; FungiDB:YALI0_D26279g; -.
DR   HOGENOM; CLU_020445_3_1_1; -.
DR   InParanoid; Q6C7Q4; -.
DR   OMA; PITDFNW; -.
DR   Proteomes; UP000001300; Chromosome D.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0033698; C:Rpd3L complex; IBA:GO_Central.
DR   GO; GO:0070210; C:Rpd3L-Expanded complex; IBA:GO_Central.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR   GO; GO:0016575; P:histone deacetylation; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR022052; Histone-bd_RBBP4_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF12265; CAF1C_H4-bd; 1.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Cytoplasm; Nucleus; Reference proteome; Repeat;
KW   WD repeat.
FT   CHAIN           1..452
FT                   /note="Histone acetyltransferase type B subunit 2"
FT                   /id="PRO_0000227745"
FT   REPEAT          155..195
FT                   /note="WD 1"
FT   REPEAT          205..245
FT                   /note="WD 2"
FT   REPEAT          256..296
FT                   /note="WD 3"
FT   REPEAT          300..340
FT                   /note="WD 4"
FT   REPEAT          344..384
FT                   /note="WD 5"
FT   REPEAT          401..441
FT                   /note="WD 6"
SQ   SEQUENCE   452 AA;  50303 MW;  E5D751744EE8C851 CRC64;
     MSATKSAGPT TLANHLDKEV KTDVLGAIDS DKLTEATQGD HKAINEEYKI WKKNSPYLYN
     VVIATVMDHP TLTVEWLPDL FDDITPGSMS ARLMFGSHSS GLDKDYIHVA SVELPTHLRP
     ETIGLLSQQE GGTDMKQHHD AHGRHKRIAI VQSIYEDGEV NVARYNPLAS KQIAAAHVTG
     DIHIFDRNNI MNSKEEAKPI YNLKHHTKEG WGLNWNINHA DQLVSGAIDS TVAFWKIPEA
     ASDGSCKDVT PHTVYHHDAA VNDVKFSYKM DFLIGSASDD CTLRLWDTRK PGNKAACTIK
     ESRGINSLDF NPHSEFLVAT GSADETVKVW DMRKMDTPIS QLYSHCDEVT KVQWCPHQPS
     VLASGGHDRA ILVWDIARLH DDLSSDENDE GPPELLFHHG GHSSRISDFD WHPTLPWVIA
     SAAEDNVIQV WRMAESISND EAVPADDVDM ED