HAT2_GIBZE
ID HAT2_GIBZE Reviewed; 433 AA.
AC Q4I7L0; A0A0E0SAZ2; I1RRR3;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-SEP-2016, sequence version 2.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=Histone acetyltransferase type B subunit 2;
GN Name=HAT2; ORFNames=FGRRES_16720, FGSG_06798;
OS Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084
OS / PH-1) (Wheat head blight fungus) (Fusarium graminearum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=229533;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=17823352; DOI=10.1126/science.1143708;
RA Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A.,
RA Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T.,
RA Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S., Goswami R.S.,
RA Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S.,
RA Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R.,
RA Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T.,
RA Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT "The Fusarium graminearum genome reveals a link between localized
RT polymorphism and pathogen specialization.";
RL Science 317:1400-1402(2007).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=26198851; DOI=10.1186/s12864-015-1756-1;
RA King R., Urban M., Hammond-Kosack M.C.U., Hassani-Pak K.,
RA Hammond-Kosack K.E.;
RT "The completed genome sequence of the pathogenic ascomycete fungus Fusarium
RT graminearum.";
RL BMC Genomics 16:544-544(2015).
CC -!- FUNCTION: Regulatory subunit of the histone acetylase B (HAT-B)
CC complex. The complex acetylates 'Lys-12' of histone H4 which is
CC required for telomeric silencing. {ECO:0000250|UniProtKB:P39984}.
CC -!- SUBUNIT: Component of the HAT-B complex composed of at least HAT1 and
CC HAT2. The HAT-B complex binds to histone H4 tail.
CC {ECO:0000250|UniProtKB:P39984}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ESU12943.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; DS231666; ESU12943.1; ALT_SEQ; Genomic_DNA.
DR EMBL; HG970335; CEF83605.1; -; Genomic_DNA.
DR RefSeq; XP_011326450.1; XM_011328148.1.
DR AlphaFoldDB; Q4I7L0; -.
DR SMR; Q4I7L0; -.
DR STRING; 5518.FGSG_06798P0; -.
DR EnsemblFungi; ESU12943; ESU12943; FGSG_06798.
DR GeneID; 23553913; -.
DR KEGG; fgr:FGSG_06798; -.
DR VEuPathDB; FungiDB:FGRAMPH1_01G23213; -.
DR eggNOG; KOG0264; Eukaryota.
DR HOGENOM; CLU_020445_3_1_1; -.
DR InParanoid; Q4I7L0; -.
DR Proteomes; UP000070720; Chromosome 4.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR022052; Histone-bd_RBBP4_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF12265; CAF1C_H4-bd; 1.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Chromatin regulator; Cytoplasm; Nucleus; Reference proteome; Repeat;
KW WD repeat.
FT CHAIN 1..433
FT /note="Histone acetyltransferase type B subunit 2"
FT /id="PRO_0000227740"
FT REPEAT 131..171
FT /note="WD 1"
FT REPEAT 184..224
FT /note="WD 2"
FT REPEAT 234..274
FT /note="WD 3"
FT REPEAT 281..321
FT /note="WD 4"
FT REPEAT 325..365
FT /note="WD 5"
FT REPEAT 382..422
FT /note="WD 6"
FT REGION 367..371
FT /note="Interaction with the histone H4 N-terminus"
FT /evidence="ECO:0000250|UniProtKB:P39984"
FT SITE 298
FT /note="Important for interaction with HAT1"
FT /evidence="ECO:0000250|UniProtKB:P39984"
SQ SEQUENCE 433 AA; 48364 MW; 36601F8864D679FF CRC64;
MAPAASADHD MDVDMIHDEE DDQGERLINE EYKTWKKNSP FLTALTWPTL TVQWFPDVKE
PEGKNYKIHR LLLGTHTSDE SPNYLQIADV QIPKVVAPNP DDYDEERGEI GGYGKSGDVA
AIKCDIVQRI EHPGEVNKAR YQPQNPDILA TLCVDGKILI FDRTKHPLDP TSTGKVNAQI
ELVGHEAEGF GLNWNPHEEG CLASGSEDTT MRLWDLKTLK ADSRILNPSR TYRHHTQIVN
DVQYHPISKN FIGSVSDDQT LQIVDIRHSE TNKAAVVAKR GHLDAINALA FNPNSEVLVA
TASADKTIGI WDLRNVKEKV HTLEGHNDAV TSLAWHPTEA GILGSASYDR RIIFWDLSRV
GEEQLPDDQD DGPPELLFMH GGHTNHLADF SWNPNEPWLV ASAAEDNLLQ IWKVAESIVG
KDDGDLPIDE LDR
