HAT2_DEBHA
ID HAT2_DEBHA Reviewed; 415 AA.
AC Q6BK34;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=Histone acetyltransferase type B subunit 2;
GN Name=HAT2; OrderedLocusNames=DEHA2F25234g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Regulatory subunit of the histone acetylase B (HAT-B)
CC complex. The complex acetylates 'Lys-12' of histone H4 which is
CC required for telomeric silencing. {ECO:0000250|UniProtKB:P39984}.
CC -!- SUBUNIT: Component of the HAT-B complex composed of at least HAT1 and
CC HAT2. The HAT-B complex binds to histone H4 tail. {ECO:0000250,
CC ECO:0000250|UniProtKB:P39984}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
CC {ECO:0000305}.
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DR EMBL; CR382138; CAG89852.1; -; Genomic_DNA.
DR RefSeq; XP_461437.1; XM_461437.1.
DR AlphaFoldDB; Q6BK34; -.
DR SMR; Q6BK34; -.
DR STRING; 4959.XP_461437.1; -.
DR EnsemblFungi; CAG89852; CAG89852; DEHA2F25234g.
DR GeneID; 2903203; -.
DR KEGG; dha:DEHA2F25234g; -.
DR VEuPathDB; FungiDB:DEHA2F25234g; -.
DR eggNOG; KOG0264; Eukaryota.
DR HOGENOM; CLU_020445_3_1_1; -.
DR InParanoid; Q6BK34; -.
DR OMA; PHEEGCL; -.
DR OrthoDB; 831322at2759; -.
DR Proteomes; UP000000599; Chromosome F.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR022052; Histone-bd_RBBP4_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF12265; CAF1C_H4-bd; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Chromatin regulator; Cytoplasm; Nucleus; Reference proteome; Repeat;
KW WD repeat.
FT CHAIN 1..415
FT /note="Histone acetyltransferase type B subunit 2"
FT /id="PRO_0000227738"
FT REPEAT 118..158
FT /note="WD 1"
FT REPEAT 163..203
FT /note="WD 2"
FT REPEAT 211..251
FT /note="WD 3"
FT REPEAT 256..296
FT /note="WD 4"
FT REPEAT 307..347
FT /note="WD 5"
FT REPEAT 364..404
FT /note="WD 6"
FT REGION 349..353
FT /note="Interaction with the histone H4 N-terminus"
FT /evidence="ECO:0000250|UniProtKB:P39984"
FT SITE 273
FT /note="Important for interaction with HAT1"
FT /evidence="ECO:0000250|UniProtKB:P39984"
SQ SEQUENCE 415 AA; 46604 MW; C84C71E83E38A6EC CRC64;
MSLEAEVPEL GQDDSQRELT IKEEYQLWRK NCRYMYEFVS ETALTWPSLT IQWLPENKTN
EAEGLIDAKL LLGTHTSGED TNYLKLASTQ IPLSNSSNTE EKSNKKVTSR IKITKKFENN
FEINRARYMP QDPSIVSTIN GAGEIDLYNL GGDQKTAIAH FTPHEDNGYG LSWSPHKKGY
LLTASDDKTV VLTDTSRLDA TDLSQVCKFT THKDIVNDAK WHQFDESLFG SVSDDKYFYL
FDIRTPGEPV SKFYHPESEG INSLSFSPFS QYLVATGNAN SNISLLDTRK LSTKSAVSDG
LLHTMMGHSD SITSLEFSPH KDGMLASGSQ DRRLILWDLF KVGEEQAQED AEDGCPELFM
MHAGHTGAVT DLSWCPYKDW TIGSVADDNI VHLWEIGKTL LNAEKGIELK DTDLE
