ID   HAT2_CANAL              Reviewed;         382 AA.
AC   Q59RH5; A0A1D8PQF8;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Histone acetyltransferase type B subunit 2;
GN   Name=HAT2; OrderedLocusNames=CAALFM_C604540CA;
GN   ORFNames=CaO19.2146, CaO19.9693;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Regulatory subunit of the histone acetylase B (HAT-B)
CC       complex. The complex acetylates 'Lys-14' of histone H4 which is
CC       required for telomeric silencing. {ECO:0000250|UniProtKB:P39984}.
CC   -!- SUBUNIT: Component of the HAT-B complex composed of at least HAT1 and
CC       HAT2. The HAT-B complex binds to histone H4 tail.
CC       {ECO:0000250|UniProtKB:P39984}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
CC       {ECO:0000305}.
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DR   EMBL; CP017628; AOW30370.1; -; Genomic_DNA.
DR   RefSeq; XP_712421.1; XM_707328.1.
DR   AlphaFoldDB; Q59RH5; -.
DR   SMR; Q59RH5; -.
DR   STRING; 237561.Q59RH5; -.
DR   GeneID; 3645973; -.
DR   KEGG; cal:CAALFM_C604540CA; -.
DR   CGD; CAL0000185853; HAT2.
DR   VEuPathDB; FungiDB:C6_04540C_A; -.
DR   eggNOG; KOG0264; Eukaryota.
DR   HOGENOM; CLU_020445_3_1_1; -.
DR   InParanoid; Q59RH5; -.
DR   OMA; PHEEGCL; -.
DR   OrthoDB; 831322at2759; -.
DR   PRO; PR:Q59RH5; -.
DR   Proteomes; UP000000559; Chromosome 6.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IDA:CGD.
DR   GO; GO:0033698; C:Rpd3L complex; IBA:GO_Central.
DR   GO; GO:0070210; C:Rpd3L-Expanded complex; IBA:GO_Central.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IMP:CGD.
DR   GO; GO:0034614; P:cellular response to reactive oxygen species; IMP:CGD.
DR   GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR   GO; GO:0016573; P:histone acetylation; IDA:CGD.
DR   GO; GO:0016575; P:histone deacetylation; IBA:GO_Central.
DR   GO; GO:2000221; P:negative regulation of pseudohyphal growth; IMP:CGD.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR022052; Histone-bd_RBBP4_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF12265; CAF1C_H4-bd; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Cytoplasm; Nucleus; Reference proteome; Repeat;
KW   WD repeat.
FT   CHAIN           1..382
FT                   /note="Histone acetyltransferase type B subunit 2"
FT                   /id="PRO_0000227735"
FT   REPEAT          98..138
FT                   /note="WD 1"
FT   REPEAT          141..181
FT                   /note="WD 2"
FT   REPEAT          184..224
FT                   /note="WD 3"
FT   REPEAT          228..268
FT                   /note="WD 4"
FT   REPEAT          275..315
FT                   /note="WD 5"
FT   REPEAT          332..372
FT                   /note="WD 6"
FT   REGION          317..321
FT                   /note="Interaction with the histone H4 N-terminus"
FT                   /evidence="ECO:0000250|UniProtKB:P39984"
FT   SITE            245
FT                   /note="Important for interaction with HAT1"
FT                   /evidence="ECO:0000250|UniProtKB:P39984"
SQ   SEQUENCE   382 AA;  42856 MW;  EC2E4DE6C2A4022E CRC64;
     MSEQPTEPLS IKEEYQLWRK NCRYMYEFVS ETALMWPSLT IQWLPNYTTT NGLIDAKLLL
     GTHTSNQSAN QLKVASTQLS ADPNVKANSK IKTVQKLENN AEICRARYMP QDANIVATIN
     GLGEVDLYNL DTETRYSHFA PHTKNGYGLS WNPKQKGLLV TGADDNFVCV TDTTTNKTTF
     KSDIQKDIVN DVKWHQFNGN LFASVSEDSH VYLFDARDNK VVSQYYAESS NGINSLAFSP
     FAENLVAIGN TSSNINLLDL RKLGENSGLL HTMMGHSEGI TCMEFSPHHD GILATGSQDR
     RIIIWDLFKV GEEQQQEDAE DGCPELFMMH AGHTAGVSDL SWCPFKDWMI GSVADDNIVH
     LWEISKKLIT NEEAEVDVSI LE