HAT14_ARATH
ID HAT14_ARATH Reviewed; 336 AA.
AC P46665; Q0WTX1; Q3E9K4; Q84TE1;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 3.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Homeobox-leucine zipper protein HAT14;
DE AltName: Full=Homeodomain-leucine zipper protein HAT14;
DE Short=HD-ZIP protein 14;
GN Name=HAT14; OrderedLocusNames=At5g06710; ORFNames=MPH15.6;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Sessa G., Carabelli M., Ciarbelli A.R., Ruzza V., Steindler C., Ruberti I.;
RT "Nucleotide sequence of the Arabidopsis HAT14 mRNA, encoding an HD-Zip II
RT protein related to ATHB-2.";
RL Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP SEQUENCE REVISION TO 1-111.
RA Carabelli M.;
RL Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 172-336 (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=7915839; DOI=10.1073/pnas.91.18.8393;
RA Schena M., Davis R.W.;
RT "Structure of homeobox-leucine zipper genes suggests a model for the
RT evolution of gene families.";
RL Proc. Natl. Acad. Sci. U.S.A. 91:8393-8397(1994).
RN [8]
RP GENE FAMILY.
RX PubMed=16055682; DOI=10.1104/pp.105.063461;
RA Henriksson E., Olsson A.S.B., Johannesson H., Johansson H., Hanson J.,
RA Engstroem P., Soederman E.;
RT "Homeodomain leucine zipper class I genes in Arabidopsis. Expression
RT patterns and phylogenetic relationships.";
RL Plant Physiol. 139:509-518(2005).
CC -!- FUNCTION: Probable transcription factor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P46665-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P46665-2; Sequence=VSP_033326, VSP_033327;
CC -!- SIMILARITY: Belongs to the HD-ZIP homeobox family. Class II subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB09805.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AJ431182; CAD24012.2; -; mRNA.
DR EMBL; AP002032; BAB09805.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED91053.1; -; Genomic_DNA.
DR EMBL; CP002688; AED91054.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM70497.1; -; Genomic_DNA.
DR EMBL; BT005879; AAO64814.1; -; mRNA.
DR EMBL; AK227423; BAE99427.1; -; mRNA.
DR EMBL; U09334; AAA56900.1; -; mRNA.
DR PIR; T52367; T52367.
DR RefSeq; NP_001332103.1; NM_001342900.1. [P46665-2]
DR RefSeq; NP_196289.2; NM_120754.5. [P46665-1]
DR RefSeq; NP_974743.1; NM_203014.3. [P46665-2]
DR AlphaFoldDB; P46665; -.
DR SMR; P46665; -.
DR BioGRID; 15839; 8.
DR IntAct; P46665; 8.
DR STRING; 3702.AT5G06710.1; -.
DR iPTMnet; P46665; -.
DR PaxDb; P46665; -.
DR PRIDE; P46665; -.
DR ProteomicsDB; 230126; -. [P46665-1]
DR EnsemblPlants; AT5G06710.1; AT5G06710.1; AT5G06710. [P46665-1]
DR EnsemblPlants; AT5G06710.2; AT5G06710.2; AT5G06710. [P46665-2]
DR EnsemblPlants; AT5G06710.3; AT5G06710.3; AT5G06710. [P46665-2]
DR GeneID; 830560; -.
DR Gramene; AT5G06710.1; AT5G06710.1; AT5G06710. [P46665-1]
DR Gramene; AT5G06710.2; AT5G06710.2; AT5G06710. [P46665-2]
DR Gramene; AT5G06710.3; AT5G06710.3; AT5G06710. [P46665-2]
DR KEGG; ath:AT5G06710; -.
DR Araport; AT5G06710; -.
DR TAIR; locus:2170194; AT5G06710.
DR eggNOG; KOG0483; Eukaryota.
DR HOGENOM; CLU_049516_1_1_1; -.
DR InParanoid; P46665; -.
DR PhylomeDB; P46665; -.
DR PRO; PR:P46665; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; P46665; baseline and differential.
DR Genevisible; P46665; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003106; Leu_zip_homeo.
DR Pfam; PF02183; HALZ; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00340; HALZ; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..336
FT /note="Homeobox-leucine zipper protein HAT14"
FT /id="PRO_0000049140"
FT DNA_BIND 187..246
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 53..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 160..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 254..275
FT /note="Leucine-zipper"
FT COMPBIAS 62..82
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 215..237
FT /note="KQKIALAKQLNLRPRQVEVWFQN -> VRVPFFTVFIYLKFVFLEFILFF
FT (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_033326"
FT VAR_SEQ 238..336
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_033327"
FT CONFLICT 203
FT /note="E -> K (in Ref. 5; AAO64814)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 336 AA; 37603 MW; BB68D0EFB45EFCA7 CRC64;
MELALSLGDN TKKQFSFMEK NSKINNPSVS STSTSEKDLG FCMALDVAFG GHRSLSSSSS
PSVEDEKKKP APRAKKSDEF RVSSSVDPPL QLQLHFPNWL PENSKGRQGG RMPLGAATVV
EEEEEEEEAV PSMSVSPPDS VTSSFQLDFG IKSYGYERRS NKRDIDDEVE RSASRASNED
NDDENGSTRK KLRLSKDQSA FLEDSFKEHS TLNPKQKIAL AKQLNLRPRQ VEVWFQNRRA
RTKLKQTEVD CEYLKRCCES LTEENRRLQK EVKELRTLKT STPFYMQLPA TTLTMCPSCE
RVATSAAQPS TSAAHNLCLS TSSLIPVKPR PAKQVS
