ID   HASC2_STRP8             Reviewed;         299 AA.
AC   P67070; P58098;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=UTP--glucose-1-phosphate uridylyltransferase 2;
DE            EC=2.7.7.9;
DE   AltName: Full=Alpha-D-glucosyl-1-phosphate uridylyltransferase 2;
DE   AltName: Full=UDP-glucose pyrophosphorylase 2;
DE            Short=UDPGP 2;
DE   AltName: Full=Uridine diphosphoglucose pyrophosphorylase 2;
GN   Name=hasC2; Synonyms=hasC.2; OrderedLocusNames=spyM18_0210;
OS   Streptococcus pyogenes serotype M18 (strain MGAS8232).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=186103;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGAS8232;
RX   PubMed=11917108; DOI=10.1073/pnas.062526099;
RA   Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S.,
RA   Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F., Parkins L.D.,
RA   Beres S.B., Campbell D.S., Smith T.M., Zhang Q., Kapur V., Daly J.A.,
RA   Veasy L.G., Musser J.M.;
RT   "Genome sequence and comparative microarray analysis of serotype M18 group
RT   A Streptococcus strains associated with acute rheumatic fever outbreaks.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-
CC         alpha-D-glucose; Xref=Rhea:RHEA:19889, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:58601,
CC         ChEBI:CHEBI:58885; EC=2.7.7.9;
CC   -!- PATHWAY: Carbohydrate metabolism; nucleotide-sugar metabolism.
CC   -!- SIMILARITY: Belongs to the UDPGP type 2 family. {ECO:0000305}.
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DR   EMBL; AE009949; AAL97000.1; -; Genomic_DNA.
DR   RefSeq; WP_002986125.1; NC_003485.1.
DR   AlphaFoldDB; P67070; -.
DR   SMR; P67070; -.
DR   GeneID; 57852025; -.
DR   KEGG; spm:spyM18_0210; -.
DR   HOGENOM; CLU_029499_1_2_9; -.
DR   OMA; FSATIWD; -.
DR   UniPathway; UPA00215; -.
DR   GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro.
DR   CDD; cd02541; UGPase_prokaryotic; 1.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR005771; GalU_uridylyltTrfase_bac/arc.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR43197; PTHR43197; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   TIGRFAMs; TIGR01099; galU; 1.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase; Transferase.
FT   CHAIN           1..299
FT                   /note="UTP--glucose-1-phosphate uridylyltransferase 2"
FT                   /id="PRO_0000201375"
SQ   SEQUENCE   299 AA;  33302 MW;  D927314E58F6091B CRC64;
     MTKVRKAIIP AAGLGTRFLP ATKALAKEML PIVDKPTIQF IVEEALKSGI EEILIVTGKS
     KRSIEDHFDS NFELEYNLQA KGKIELLKLV DETTSINLHF IRQSHPRGLG DAVLQAKTFV
     GNEPFVVMLG DDLMDITNPN VKPLTKQLID DYEETHAATI AVMRVPHEDV SNYGIIAPQA
     KAVKGLYSVD TFVEKPQPQD APSDLAIIGR YLLTPEIFSI LEKQEPGAGN EVQLTDAIDT
     LNKTQRVFAR EFKGKRYDVG DKFGFMKTSL DYALKHPQVK DDLKAYIIQL GKALEKTKP