ID   HASC2_STRP6             Reviewed;         304 AA.
AC   Q5X9A7;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=UTP--glucose-1-phosphate uridylyltransferase 2;
DE            EC=2.7.7.9;
DE   AltName: Full=Alpha-D-glucosyl-1-phosphate uridylyltransferase 2;
DE   AltName: Full=UDP-glucose pyrophosphorylase 2;
DE            Short=UDPGP 2;
DE   AltName: Full=Uridine diphosphoglucose pyrophosphorylase 2;
GN   Name=hasC2; Synonyms=hasC.2; OrderedLocusNames=M6_Spy1871;
OS   Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=286636;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-946 / MGAS10394;
RX   PubMed=15272401; DOI=10.1086/422697;
RA   Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E.,
RA   Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.;
RT   "Progress toward characterization of the group A Streptococcus metagenome:
RT   complete genome sequence of a macrolide-resistant serotype M6 strain.";
RL   J. Infect. Dis. 190:727-738(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-
CC         alpha-D-glucose; Xref=Rhea:RHEA:19889, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:58601,
CC         ChEBI:CHEBI:58885; EC=2.7.7.9;
CC   -!- PATHWAY: Carbohydrate metabolism; nucleotide-sugar metabolism.
CC   -!- SIMILARITY: Belongs to the UDPGP type 2 family. {ECO:0000305}.
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DR   EMBL; CP000003; AAT88006.1; -; Genomic_DNA.
DR   RefSeq; WP_002982024.1; NC_006086.1.
DR   AlphaFoldDB; Q5X9A7; -.
DR   SMR; Q5X9A7; -.
DR   EnsemblBacteria; AAT88006; AAT88006; M6_Spy1871.
DR   GeneID; 57853531; -.
DR   KEGG; spa:M6_Spy1871; -.
DR   HOGENOM; CLU_029499_1_2_9; -.
DR   OMA; MHYVRQG; -.
DR   UniPathway; UPA00215; -.
DR   Proteomes; UP000001167; Chromosome.
DR   GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro.
DR   CDD; cd02541; UGPase_prokaryotic; 1.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR005771; GalU_uridylyltTrfase_bac/arc.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR43197; PTHR43197; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   TIGRFAMs; TIGR01099; galU; 1.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase; Transferase.
FT   CHAIN           1..304
FT                   /note="UTP--glucose-1-phosphate uridylyltransferase 2"
FT                   /id="PRO_0000201374"
SQ   SEQUENCE   304 AA;  33706 MW;  5D717DF01DBC4411 CRC64;
     MTKVRKAIIP AAGLGTRFLP ATKALAKEML PIVDKPTIQF IVEEALKSGI EEILVVTGKA
     KRSIEDHFDS NFELEYNLQA KGKNELLKLV DETTAINLHF IRQSHPRGLG DAVLQAKAFV
     GNEPFVVMLG DDLMDITNAS AKPLTKQLME DYDKTHASTI AVMKVPHEDV SSYGVIAPQG
     KAVKGLYSVD TFVEKPQPED APSDLAIIGR YLLTPEIFDI LERQVPGAGN EVQLTDAIDT
     LNKTQRVFAR EFKGNRYDVG DKFGFMKTSI DYALEHPQVK EDLKNYIIKL GKALEKSKVP
     THSK