ID   HASC2_STRP1             Reviewed;         299 AA.
AC   P67068; P58098; Q491A7;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=UTP--glucose-1-phosphate uridylyltransferase 2;
DE            EC=2.7.7.9;
DE   AltName: Full=Alpha-D-glucosyl-1-phosphate uridylyltransferase 2;
DE   AltName: Full=UDP-glucose pyrophosphorylase 2;
DE            Short=UDPGP 2;
DE   AltName: Full=Uridine diphosphoglucose pyrophosphorylase 2;
GN   Name=hasC2; Synonyms=hasC.2; OrderedLocusNames=SPy_0224, M5005_Spy0192;
OS   Streptococcus pyogenes serotype M1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX   PubMed=11296296; DOI=10.1073/pnas.071559398;
RA   Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA   Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA   Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA   Clifton S.W., Roe B.A., McLaughlin R.E.;
RT   "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX   PubMed=16088826; DOI=10.1086/432514;
RA   Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA   Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA   Musser J.M.;
RT   "Evolutionary origin and emergence of a highly successful clone of serotype
RT   M1 group A Streptococcus involved multiple horizontal gene transfer
RT   events.";
RL   J. Infect. Dis. 192:771-782(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-
CC         alpha-D-glucose; Xref=Rhea:RHEA:19889, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:58601,
CC         ChEBI:CHEBI:58885; EC=2.7.7.9;
CC   -!- PATHWAY: Carbohydrate metabolism; nucleotide-sugar metabolism.
CC   -!- SIMILARITY: Belongs to the UDPGP type 2 family. {ECO:0000305}.
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DR   EMBL; AE004092; AAK33308.1; -; Genomic_DNA.
DR   EMBL; CP000017; AAZ50811.1; -; Genomic_DNA.
DR   RefSeq; NP_268587.1; NC_002737.2.
DR   AlphaFoldDB; P67068; -.
DR   SMR; P67068; -.
DR   STRING; 1314.HKU360_00234; -.
DR   PaxDb; P67068; -.
DR   EnsemblBacteria; AAK33308; AAK33308; SPy_0224.
DR   KEGG; spy:SPy_0224; -.
DR   KEGG; spz:M5005_Spy0192; -.
DR   PATRIC; fig|160490.10.peg.199; -.
DR   HOGENOM; CLU_029499_1_2_9; -.
DR   OMA; FSATIWD; -.
DR   UniPathway; UPA00215; -.
DR   Proteomes; UP000000750; Chromosome.
DR   GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro.
DR   CDD; cd02541; UGPase_prokaryotic; 1.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR005771; GalU_uridylyltTrfase_bac/arc.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR43197; PTHR43197; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   TIGRFAMs; TIGR01099; galU; 1.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..299
FT                   /note="UTP--glucose-1-phosphate uridylyltransferase 2"
FT                   /id="PRO_0000201372"
SQ   SEQUENCE   299 AA;  33302 MW;  D927314E58F6091B CRC64;
     MTKVRKAIIP AAGLGTRFLP ATKALAKEML PIVDKPTIQF IVEEALKSGI EEILIVTGKS
     KRSIEDHFDS NFELEYNLQA KGKIELLKLV DETTSINLHF IRQSHPRGLG DAVLQAKTFV
     GNEPFVVMLG DDLMDITNPN VKPLTKQLID DYEETHAATI AVMRVPHEDV SNYGIIAPQA
     KAVKGLYSVD TFVEKPQPQD APSDLAIIGR YLLTPEIFSI LEKQEPGAGN EVQLTDAIDT
     LNKTQRVFAR EFKGKRYDVG DKFGFMKTSL DYALKHPQVK DDLKAYIIQL GKALEKTKP