ID   HAS8_HALS8              Reviewed;         311 AA.
AC   Q9HHA8;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Halocin-S8;
DE   Flags: Precursor;
GN   Name=halS8;
OS   Haloarchaeon S8a.
OG   Plasmid.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae.
OX   NCBI_TaxID=135836;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 231-266.
RX   PubMed=10940040; DOI=10.1128/jb.182.17.4951-4958.2000;
RA   Price L.B., Shand R.F.;
RT   "Halocin S8: a 36-amino-acid microhalocin from the haloarchaeal strain
RT   S8a.";
RL   J. Bacteriol. 182:4951-4958(2000).
CC   -!- FUNCTION: Has antibacterial activity against the haloarchaeons
CC       H.salinarium NRC817, Halobacterium GRB and H.gibbonsii.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MISCELLANEOUS: Halocin-S8 is quite robust, as it can be desalted,
CC       boiled, subjected to organic solvents, and stored at 4 degrees Celsius
CC       for extended periods without losing activity.
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DR   EMBL; AF276080; AAG10010.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9HHA8; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR006311; TAT_signal.
DR   PROSITE; PS51318; TAT; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Bacteriocin; Direct protein sequencing; Plasmid;
KW   Secreted.
FT   PROPEP          1..230
FT                   /evidence="ECO:0000269|PubMed:10940040"
FT                   /id="PRO_0000013170"
FT   PEPTIDE         231..266
FT                   /note="Halocin-S8"
FT                   /id="PRO_0000013171"
FT   PROPEP          267..311
FT                   /id="PRO_0000013172"
SQ   SEQUENCE   311 AA;  33963 MW;  D3EB40CFAC3864E9 CRC64;
     MSDKDSINRR NVLRKIGGIG VASAVGFSGL ASGESLSDDE KQDVIDTIYK SQRVEQIKKK
     FGGVNIEPKK VQSVTTNQSG DLVTAKLSVS DGDLVYSSVK DTTVIVQFDR SASEIGESWP
     KNTEAFIKST SSGVDLLRTA TDEEIKDVTE GVNTSEIESA DAVNIFIDPE SQTYYMEKYD
     FNNKVLEMFE LATGGTSSGK ISPTREDQNH EYNVREHKVF NSEKQNIQLQ SDCNINSNTA
     ADVILCFNQV GSCALCSPTL VGGPVPTVAC LLVVCFGTPN AVSAILEEVD NSCFNLIKDV
     ISCWDEWTSF W