ID   HAS3P_HUMAN             Reviewed;          53 AA.
AC   C0HLZ6;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   23-FEB-2022, sequence version 1.
DT   03-AUG-2022, entry version 3.
DE   RecName: Full=HOXB-AS3 peptide {ECO:0000303|PubMed:28985503};
GN   Name=HOXB-AS3 {ECO:0000312|HGNC:HGNC:40283};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000305}
RP   IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, AND INTERACTION WITH
RP   HNRNPA1.
RX   PubMed=28985503; DOI=10.1016/j.molcel.2017.09.015;
RA   Huang J.Z., Chen M., Chen D., Gao X.C., Zhu S., Huang H., Hu M., Zhu H.,
RA   Yan G.R.;
RT   "A Peptide Encoded by a Putative lncRNA HOXB-AS3 Suppresses Colon Cancer
RT   Growth.";
RL   Mol. Cell 68:171-184(2017).
RN   [3] {ECO:0000305}
RP   FUNCTION, AND INTERACTION WITH IGF2BP2.
RX   PubMed=34457052; DOI=10.3892/ol.2021.12958;
RA   Leng F., Miu Y.Y., Zhang Y., Luo H., Lu X.L., Cheng H., Zheng Z.G.;
RT   "A micro-peptide encoded by HOXB-AS3 promotes the proliferation and
RT   viability of oral squamous cell carcinoma cell lines by directly binding
RT   with IGF2BP2 to stabilize c-Myc.";
RL   Oncol. Lett. 22:697-697(2021).
CC   -!- FUNCTION: Blocks the binding of HNRNPA1 to the intronic sequences
CC       flanking exon 9 of the PKM gene by competitively binding to the HNRNPA1
CC       RGG-box motif (PubMed:28985503). This inhibits inclusion of exon 9 and
CC       promotes inclusion of exon 10, suppressing formation of the PKM M2
CC       isoform and promoting production of the M1 isoform (PubMed:28985503).
CC       Also suppresses HNRNPA1-mediated processing of microRNA 18a (miR-18a)
CC       (PubMed:28985503). Promotes MYC stability through interaction with
CC       IGF2BP2 (PubMed:34457052). {ECO:0000269|PubMed:28985503,
CC       ECO:0000269|PubMed:34457052}.
CC   -!- SUBUNIT: Interacts with HNRNPA1 (via the RGG-box) (PubMed:28985503).
CC       Interacts with IGF2BP2 (PubMed:34457052). {ECO:0000269|PubMed:28985503,
CC       ECO:0000269|PubMed:34457052}.
CC   -!- MISCELLANEOUS: By blocking HNRNPA1-dependent PKM splicing, inhibits
CC       colon cancer cell aerobic glycolysis and suppresses colon cancer cell
CC       growth, colony formation, migration and invasion (PubMed:28985503).
CC       Promotes the proliferation and viability of oral squamous cell
CC       carcinoma cells (PubMed:34457052). {ECO:0000269|PubMed:28985503,
CC       ECO:0000269|PubMed:34457052}.
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DR   EMBL; AC103702; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   HGNC; HGNC:40283; HOXB-AS3.
DR   Proteomes; UP000005640; Unplaced.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:2000632; P:negative regulation of pre-miRNA processing; IDA:UniProtKB.
DR   GO; GO:0050821; P:protein stabilization; IMP:UniProtKB.
DR   GO; GO:0043484; P:regulation of RNA splicing; IMP:UniProtKB.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   mRNA processing; mRNA splicing; Reference proteome.
FT   CHAIN           1..53
FT                   /note="HOXB-AS3 peptide"
FT                   /id="PRO_0000455048"
FT   REGION          1..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   53 AA;  5567 MW;  E4C717A85FF688D7 CRC64;
     MPVLPGTQRY PHQRRRFQAA GGGAESGKRG SEEAPGVAWS GSESGRDAAT PAW