HAND2_DANRE
ID HAND2_DANRE Reviewed; 208 AA.
AC P57102;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Heart- and neural crest derivatives-expressed protein 2;
DE AltName: Full=Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2;
DE Short=dHAND;
GN Name=hand2; Synonyms=dhand;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Embryo;
RX PubMed=10906469; DOI=10.1016/s0925-4773(00)00334-8;
RA Angelo S., Lohr J., Lee K.H., Ticho B.S., Breitbart R.E., Hill S.,
RA Yost H.J., Srivastava D.;
RT "Conservation of sequence and expression of Xenopus and zebrafish dHAND
RT during cardiac, branchial arch and lateral mesoderm development.";
RL Mech. Dev. 95:231-237(2000).
RN [2]
RP FUNCTION.
RX PubMed=10821756; DOI=10.1242/dev.127.12.2573;
RA Yelon D., Ticho B.S., Halpern M.E., Ruvinsky I., Ho R.K., Silver L.M.,
RA Stainier D.Y.R.;
RT "The bHLH transcription factor hand2 plays parallel roles in zebrafish
RT heart and pectoral fin development.";
RL Development 127:2573-2582(2000).
CC -!- FUNCTION: Essential for myocardial and pectoral fin differentiation,
CC patterning and morphogenesis. {ECO:0000269|PubMed:10821756}.
CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC protein.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- DEVELOPMENTAL STAGE: Expression first detected at 8 hours post
CC fertilization (hpf) in a circumferential pattern in the lateral
CC mesoderm. At 12 hpf, still expressed in the anterior and posterior
CC lateral plate mesoderm which is partly detached from the yolk at this
CC stage. By 18-20 hpf, expressed in the cardiac ring and in a layer of
CC lateral mesoderm surrounding the cardiac region, as well as in the
CC posterior lateral mesoderm. At 24 hpf, expressed throughout the nascent
CC cardiac tube and in bilaterally symmetric clusters of ventrolateral
CC cells that condense to form branchial arch mesoderm which gives rise to
CC jaw and pharyngeal bones. Expression continues bilaterally in the
CC posterior lateral mesoderm. At 36-48 hpf, expressed in defined
CC branchial arch mesoderm populations. At 48 hpf, strong expression
CC throughout the heart tube.
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DR EMBL; AF228334; AAF67130.1; -; mRNA.
DR AlphaFoldDB; P57102; -.
DR SMR; P57102; -.
DR STRING; 7955.ENSDARP00000022921; -.
DR PaxDb; P57102; -.
DR ZFIN; ZDB-GENE-000511-1; hand2.
DR eggNOG; KOG4029; Eukaryota.
DR InParanoid; P57102; -.
DR PRO; PR:P57102; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0055007; P:cardiac muscle cell differentiation; IMP:ZFIN.
DR GO; GO:0010002; P:cardioblast differentiation; IMP:ZFIN.
DR GO; GO:0035051; P:cardiocyte differentiation; IMP:ZFIN.
DR GO; GO:0003142; P:cardiogenic plate morphogenesis; IMP:ZFIN.
DR GO; GO:0071908; P:determination of intestine left/right asymmetry; IMP:ZFIN.
DR GO; GO:0032502; P:developmental process; IBA:GO_Central.
DR GO; GO:0003144; P:embryonic heart tube formation; IMP:ZFIN.
DR GO; GO:0035118; P:embryonic pectoral fin morphogenesis; IMP:ZFIN.
DR GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IMP:ZFIN.
DR GO; GO:0060047; P:heart contraction; IMP:ZFIN.
DR GO; GO:0007507; P:heart development; IBA:GO_Central.
DR GO; GO:0001947; P:heart looping; IGI:ZFIN.
DR GO; GO:0003007; P:heart morphogenesis; IMP:ZFIN.
DR GO; GO:0003357; P:noradrenergic neuron differentiation; IMP:ZFIN.
DR GO; GO:0030859; P:polarized epithelial cell differentiation; IMP:ZFIN.
DR GO; GO:0003342; P:proepicardium development; IMP:ZFIN.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0048485; P:sympathetic nervous system development; IMP:ZFIN.
DR GO; GO:0030878; P:thyroid gland development; IMP:ZFIN.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..208
FT /note="Heart- and neural crest derivatives-expressed
FT protein 2"
FT /id="PRO_0000127194"
FT DOMAIN 90..142
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 79..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..179
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 208 AA; 23167 MW; F0E63A9329AC6E06 CRC64;
MSLVGGFPHH PVMHHDGYSF AAAAAASRCH EEPPYFHGWL ISHPEMSPPD YTMAPSYSPE
YSTGAPGLDH SHYGGVPGAG AVGMGPRTVK RRPTANRKER RRTQSINSAF AELRECIPNV
PADTKLSKIK TLRLATSYIA YLMDILDKDE QNGETEAFKA EFKKTDAKEE RRKKEMNDVL
KSSGSSNDKK TKGRTGWPQH VWALELKQ
