ID   HAND1_XENLA             Reviewed;         197 AA.
AC   O73615;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Heart- and neural crest derivatives-expressed protein 1;
DE   AltName: Full=Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1;
DE            Short=eHAND;
GN   Name=hand1; Synonyms=ehand;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryo;
RX   PubMed=9507100; DOI=10.1016/s0925-4773(98)00010-0;
RA   Sparrow D.B., Kotecha S., Towers N., Mohun T.J.;
RT   "Xenopus eHAND: a marker for the developing cardiovascular system of the
RT   embryo that is regulated by bone morphogenetic proteins.";
RL   Mech. Dev. 71:151-163(1998).
CC   -!- FUNCTION: Plays an essential role in cardiac morphogenesis.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC       Nucleus, nucleolus {ECO:0000250|UniProtKB:Q64279}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in the adult heart and expressed
CC       at lower levels in the intestine and gall bladder.
CC   -!- DEVELOPMENTAL STAGE: At stage 15, detectable in the anterior and
CC       ventral mesoderm near the heart primordia. At stage 22, the central
CC       band of expression in the lateral plate mesoderm is confined to the
CC       mid-embryo. By stages 28-30 (late tailbud stages), the region of
CC       expression in the lateral plate mesoderm has expanded into a
CC       symmetrical arc of ventral and lateral expression, which fuses in the
CC       midline where the straight heart tube has formed. At stage 33
CC       (beginning of heart looping), expressed in the heart, lateral mesoderm
CC       and branchial arches. At stage 37, uniform expression in the myocardium
CC       and cardiac outflow. Most abundant in the heart and outflow tract at
CC       stage 47 (tadpole stage).
CC   -!- INDUCTION: By bone morphogenetic proteins BMP-2 and BMP-4.
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DR   EMBL; Z95080; CAB08267.1; -; mRNA.
DR   RefSeq; NP_001079128.1; NM_001085659.1.
DR   AlphaFoldDB; O73615; -.
DR   SMR; O73615; -.
DR   GeneID; 373663; -.
DR   KEGG; xla:373663; -.
DR   CTD; 373663; -.
DR   Xenbase; XB-GENE-865344; hand1.L.
DR   OMA; YFQSWVL; -.
DR   OrthoDB; 1449816at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 373663; Expressed in heart and 6 other tissues.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..197
FT                   /note="Heart- and neural crest derivatives-expressed
FT                   protein 1"
FT                   /id="PRO_0000127190"
FT   DOMAIN          80..132
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          61..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          155..184
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   197 AA;  22001 MW;  AAA8F5B29D018E51 CRC64;
     MNLIGSYQHH HHHMMPDPFI FSPGSRCHQE RPYFQGWVLN PGEVSPEFPA QPPYSPEYGA
     VVGPSQTSGR IENLGGKLGR RKGAPPKKER RRTESINSAF AELRECIPNV PADTKLSKIK
     TLRLATSYIG YLMDVLAKDS EPGGTEAFKA EIKKVDGKRR REPQPTEGYW GAAPAGEKKL
     KGRTGWPQQV WALELNP