HAND1_CHICK
ID HAND1_CHICK Reviewed; 202 AA.
AC Q90691;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Heart- and neural crest derivatives-expressed protein 1;
DE AltName: Full=Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1;
DE Short=eHAND;
GN Name=HAND1; Synonyms=EHAND;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC TISSUE=Embryo;
RX PubMed=8533092; DOI=10.1126/science.270.5244.1995;
RA Srivastava D., Cserjesi P., Olson E.N.;
RT "A subclass of bHLH proteins required for cardiac morphogenesis.";
RL Science 270:1995-1998(1995).
CC -!- FUNCTION: Transcription factor (By similarity). Plays an essential role
CC in cardiac morphogenesis (PubMed:8533092).
CC {ECO:0000250|UniProtKB:Q64279, ECO:0000269|PubMed:8533092}.
CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC protein.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm
CC {ECO:0000250|UniProtKB:Q64279}. Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:Q64279}.
CC -!- DEVELOPMENTAL STAGE: At stage 8, detected in the cardiac crescent. At
CC stage 10, expressed throughout the cardiac tube and the sinus venosus.
CC By stage 15, expressed homogeneously in the various regions of the
CC heart, including the atria, future left ventricle, bulbus cordis and
CC truncus arteriosus, and in the forming branchial arches. Expression
CC persists through stage 20, but decreases thereafter.
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DR EMBL; U40041; AAC59734.1; -; mRNA.
DR RefSeq; NP_990296.1; NM_204965.1.
DR AlphaFoldDB; Q90691; -.
DR SMR; Q90691; -.
DR STRING; 9031.ENSGALP00000041858; -.
DR Ensembl; ENSGALT00000066170; ENSGALP00000044206; ENSGALG00000035104.
DR GeneID; 395812; -.
DR KEGG; gga:395812; -.
DR CTD; 9421; -.
DR VEuPathDB; HostDB:geneid_395812; -.
DR eggNOG; KOG4029; Eukaryota.
DR GeneTree; ENSGT00940000161111; -.
DR InParanoid; Q90691; -.
DR OMA; YFQSWVL; -.
DR OrthoDB; 1449816at2759; -.
DR PhylomeDB; Q90691; -.
DR PRO; PR:Q90691; -.
DR Proteomes; UP000000539; Chromosome 13.
DR Bgee; ENSGALG00000035104; Expressed in heart and 1 other tissue.
DR ExpressionAtlas; Q90691; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IEA:Ensembl.
DR GO; GO:0043425; F:bHLH transcription factor binding; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0001221; F:transcription coregulator binding; IEA:Ensembl.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:0003218; P:cardiac left ventricle formation; IEA:Ensembl.
DR GO; GO:0003219; P:cardiac right ventricle formation; IEA:Ensembl.
DR GO; GO:0060411; P:cardiac septum morphogenesis; IEA:Ensembl.
DR GO; GO:0060536; P:cartilage morphogenesis; IEA:Ensembl.
DR GO; GO:0030154; P:cell differentiation; IEA:Ensembl.
DR GO; GO:0032502; P:developmental process; IBA:GO_Central.
DR GO; GO:0003144; P:embryonic heart tube formation; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IBA:GO_Central.
DR GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR GO; GO:0060485; P:mesenchyme development; IEA:Ensembl.
DR GO; GO:0001707; P:mesoderm formation; IEA:Ensembl.
DR GO; GO:0043433; P:negative regulation of DNA-binding transcription factor activity; IEA:Ensembl.
DR GO; GO:1903026; P:negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IEA:Ensembl.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..202
FT /note="Heart- and neural crest derivatives-expressed
FT protein 1"
FT /id="PRO_0000127189"
FT DOMAIN 83..135
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 143..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..171
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 202 AA; 22679 MW; 1819896705268AA6 CRC64;
MNLVGGYQHH HHHHHHHHML HEPFLFGPAA RCHQERAYFP GWVLNPAEVT PELHGQSPAY
GPAEFGSGGA GRLEALSGRL GRRKGVGGPK KERRRTESIN SAFAELRECI PNVPADTKLS
KIKTLRLATS YIAYLMEVLA RDSQPGEPEG FKAELKKADG RENKRKRETQ PEVYSQPLAH
GEKKLKGRTG WPQQVWALEL NP
