ID   HANA_THEZI              Reviewed;          67 AA.
AC   P95669; O08124;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Archaeal histone HAN1 subunit A;
GN   Name=han1A;
OS   Thermococcus zilligii.
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=54076;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=AN1;
RX   PubMed=8652658; DOI=10.1016/0167-4781(96)00031-0;
RA   Ronimus R.S., Musgrave D.R.;
RT   "A gene, han1A, encoding an archaeal histone-like protein from the
RT   Thermococcus species AN1: homology with eukaryal histone consensus
RT   sequences and the implications for delineation of the histone fold.";
RL   Biochim. Biophys. Acta 1307:1-7(1996).
RN   [2]
RP   PARTIAL PROTEIN SEQUENCE, FUNCTION, AND SUBUNIT.
RC   STRAIN=AN1;
RX   PubMed=8861206; DOI=10.1111/j.1365-2958.1996.tb02490.x;
RA   Ronimus R.S., Musgrave D.R.;
RT   "Purification and characterization of a histone-like protein from the
RT   Archaeal isolate AN1, a member of the Thermococcales.";
RL   Mol. Microbiol. 20:77-86(1996).
CC   -!- FUNCTION: Binds and compact DNA (95 to 150 base pairs) to form
CC       nucleosome-like structures that contain positive DNA supercoils.
CC       Increases the resistance of DNA to thermal denaturation (in vitro).
CC       {ECO:0000269|PubMed:8861206}.
CC   -!- SUBUNIT: Heterodimer (PubMed:8861206). Dimers then assemble into higher
CC       oligomers, with the DNA wrapped around the protein core (By
CC       similarity). {ECO:0000250|UniProtKB:P19267,
CC       ECO:0000269|PubMed:8861206}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Chromosome
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the archaeal histone HMF family. {ECO:0000305}.
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DR   EMBL; U93078; AAB53861.1; -; Genomic_DNA.
DR   PIR; S71485; S71485.
DR   AlphaFoldDB; P95669; -.
DR   SMR; P95669; -.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   Gene3D; 1.10.20.10; -; 1.
DR   InterPro; IPR003958; CBFA_NFYB_domain.
DR   InterPro; IPR009072; Histone-fold.
DR   Pfam; PF00808; CBFD_NFYB_HMF; 1.
DR   SUPFAM; SSF47113; SSF47113; 1.
PE   1: Evidence at protein level;
KW   Chromosome; Cytoplasm; Direct protein sequencing; DNA-binding.
FT   INIT_MET        1
FT                   /note="Removed"
FT   CHAIN           2..67
FT                   /note="Archaeal histone HAN1 subunit A"
FT                   /id="PRO_0000155004"
FT   REGION          20..22
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250|UniProtKB:P19267"
FT   REGION          54..57
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250|UniProtKB:P19267"
SQ   SEQUENCE   67 AA;  7336 MW;  C84C2B60D3634350 CRC64;
     MAELPIAPID RLIRKAGAER VSEDAAKALA EYLEEYAIEV GKKATEFARH AGRKTVKAED
     VRLAVKA