HAM2_CAEEL
ID HAM2_CAEEL Reviewed; 392 AA.
AC H2KYH4; A3RMS1; A3RMS3;
DT 07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2012, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Zinc finger protein ham-2 {ECO:0000305};
DE AltName: Full=HSN abnormal migration protein 2 {ECO:0000312|WormBase:C07A12.1b};
GN Name=ham-2 {ECO:0000312|WormBase:C07A12.1b};
GN ORFNames=C07A12.1 {ECO:0000312|WormBase:C07A12.1b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, AND MUTAGENESIS OF
RP SER-30 AND HIS-39.
RX PubMed=10049362; DOI=10.1101/gad.13.4.472;
RA Baum P.D., Guenther C., Frank C.A., Pham B.V., Garriga G.;
RT "The Caenorhabditis elegans gene ham-2 links Hox patterning to migration of
RT the HSN motor neuron.";
RL Genes Dev. 13:472-483(1999).
CC -!- FUNCTION: Probable transcription factor that acts downstream of egl-15,
CC to promote migration of the HSN motor neurons from the tail to the
CC gonad primordium during HSN cell differentiation (PubMed:10049362).
CC {ECO:0000269|PubMed:10049362}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10049362}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=b {ECO:0000312|WormBase:C07A12.1b};
CC IsoId=H2KYH4-1; Sequence=Displayed;
CC Name=c {ECO:0000312|WormBase:C07A12.1c};
CC IsoId=H2KYH4-2; Sequence=VSP_060687;
CC Name=a {ECO:0000312|WormBase:C07A12.1a};
CC IsoId=H2KYH4-3; Sequence=VSP_060688;
CC -!- DEVELOPMENTAL STAGE: During embryogenesis, expressed in HSN motor
CC neurons (at protein level) (PubMed:10049362). Expressed in HSNs both
CC before and during cell migration (at protein level) (PubMed:10049362).
CC {ECO:0000269|PubMed:10049362}.
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DR EMBL; BX284606; CCD63271.1; -; Genomic_DNA.
DR EMBL; BX284606; CCD63272.1; -; Genomic_DNA.
DR EMBL; BX284606; CCD63273.1; -; Genomic_DNA.
DR RefSeq; NP_001024363.2; NM_001029192.4. [H2KYH4-3]
DR RefSeq; NP_001024364.2; NM_001029193.3. [H2KYH4-1]
DR RefSeq; NP_001294827.1; NM_001307898.1. [H2KYH4-2]
DR AlphaFoldDB; H2KYH4; -.
DR IntAct; H2KYH4; 51.
DR STRING; 6239.C07A12.1b; -.
DR EPD; H2KYH4; -.
DR PaxDb; H2KYH4; -.
DR EnsemblMetazoa; C07A12.1a.1; C07A12.1a.1; WBGene00001821. [H2KYH4-3]
DR EnsemblMetazoa; C07A12.1b.1; C07A12.1b.1; WBGene00001821. [H2KYH4-1]
DR EnsemblMetazoa; C07A12.1c.1; C07A12.1c.1; WBGene00001821. [H2KYH4-2]
DR GeneID; 180727; -.
DR KEGG; cel:CELE_C07A12.1; -.
DR UCSC; C07A12.1b; c. elegans.
DR CTD; 180727; -.
DR WormBase; C07A12.1a; CE39669; WBGene00001821; ham-2.
DR WormBase; C07A12.1b; CE07992; WBGene00001821; ham-2.
DR WormBase; C07A12.1c; CE39670; WBGene00001821; ham-2.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00970000196410; -.
DR HOGENOM; CLU_704449_0_0_1; -.
DR InParanoid; H2KYH4; -.
DR OMA; IHISHDQ; -.
DR OrthoDB; 858046at2759; -.
DR PhylomeDB; H2KYH4; -.
DR SignaLink; H2KYH4; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00001821; Expressed in anatomical system and 4 other tissues.
DR ExpressionAtlas; H2KYH4; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:WormBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0001709; P:cell fate determination; IMP:WormBase.
DR GO; GO:0016477; P:cell migration; IMP:WormBase.
DR GO; GO:0045664; P:regulation of neuron differentiation; IMP:WormBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:WormBase.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 1.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Zinc; Zinc-finger.
FT CHAIN 1..392
FT /note="Zinc finger protein ham-2"
FT /id="PRO_0000450750"
FT ZN_FING 16..39
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 43..66
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 72..95
FT /note="C2H2-type 3; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 106..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 278..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..61
FT /note="Missing (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_060687"
FT VAR_SEQ 112..113
FT /note="Missing (in isoform a)"
FT /evidence="ECO:0000305"
FT /id="VSP_060688"
FT MUTAGEN 30
FT /note="S->F: In gm16; causes arrest at the L1 larval stage,
FT defects in hermaphrodite-specific neuron migration, and
FT impairs pharynx attachment to the nose."
FT /evidence="ECO:0000269|PubMed:10049362"
FT MUTAGEN 39
FT /note="H->Y: In gm48; in some mutants, causes arrest at the
FT L1 larval stage and defects in hermaphrodite-specific
FT neuron migration."
FT /evidence="ECO:0000269|PubMed:10049362"
SQ SEQUENCE 392 AA; 43672 MW; EC027C509321EA9C CRC64;
MPYRAELKRP DLKGSFPCSI CQKVFCHSSS LSRHRMQAHF KSYTCTTCNN EIPSNDTLRS
HMYRVHNITR MFMCRCCNWA FPDKTSLHIH MQSMLKNGTP GEAAVLAKSS DVVDSTSESG
SPRQSPPFSP DLLMQKRMLQ VAANNNNIGS IFPTLLKSPD SKSMFPLDLS NMGPSQFLSA
WLANNPINTA ALNLAAQQTP SKDSIQSSNI SDYDDLEVQT TEEDIKFEVE SSDVSPRSVI
VKTEPTFKRE LEHDADIDVE GDDGEPPLKM TIDDKNIHIS HDQPSPTVSD SHISGGSSSH
SGESLKCFDC QVARGKLVAV EDKCRAYEKT IRELQVQVDF LRKIQPNPMP PVMLPPPMMP
MPSPGPNNLF QNPAMRMLLN NLIHMNRPSV VP
