ID   HALL_DICDI              Reviewed;         529 AA.
AC   Q556V9; Q86AJ4;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=hal-like protein DDB_G0273787/DDB_G0273081;
DE            EC=4.3.1.3;
GN   ORFNames=DDB_G0273787;
GN   and
GN   ORFNames=DDB_G0273081;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-histidine = NH4(+) + trans-urocanate; Xref=Rhea:RHEA:21232,
CC         ChEBI:CHEBI:17771, ChEBI:CHEBI:28938, ChEBI:CHEBI:57595; EC=4.3.1.3;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU10122};
CC   -!- PATHWAY: Amino-acid degradation; L-histidine degradation into L-
CC       glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- PTM: Contains an active site 4-methylidene-imidazol-5-one (MIO), which
CC       is formed autocatalytically by cyclization and dehydration of residues
CC       Ala-Ser-Gly. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PAL/histidase family. {ECO:0000305}.
CC   -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC       AX4. These strains contain a duplication of a segment of 750 kb of
CC       chromosome 2 compared to the corresponding sequence in strain AX2.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000011; EAL70584.1; -; Genomic_DNA.
DR   EMBL; AAFI02000009; EAL70758.1; -; Genomic_DNA.
DR   RefSeq; XP_644510.1; XM_639418.1.
DR   RefSeq; XP_644740.1; XM_639648.1.
DR   AlphaFoldDB; Q556V9; -.
DR   SMR; Q556V9; -.
DR   STRING; 44689.DDB0231725; -.
DR   PaxDb; Q556V9; -.
DR   EnsemblProtists; EAL70584; EAL70584; DDB_G0273787.
DR   EnsemblProtists; EAL70758; EAL70758; DDB_G0273081.
DR   GeneID; 8618840; -.
DR   GeneID; 8619136; -.
DR   KEGG; ddi:DDB_G0273081; -.
DR   KEGG; ddi:DDB_G0273787; -.
DR   dictyBase; DDB_G0273081; -.
DR   dictyBase; DDB_G0273787; -.
DR   eggNOG; KOG0222; Eukaryota.
DR   HOGENOM; CLU_014801_4_0_1; -.
DR   InParanoid; Q556V9; -.
DR   OMA; PTNLHNQ; -.
DR   PhylomeDB; Q556V9; -.
DR   Reactome; R-DDI-70921; Histidine catabolism.
DR   UniPathway; UPA00379; UER00549.
DR   PRO; PR:Q556V9; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016841; F:ammonia-lyase activity; IBA:GO_Central.
DR   GO; GO:0004397; F:histidine ammonia-lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019556; P:histidine catabolic process to glutamate and formamide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019557; P:histidine catabolic process to glutamate and formate; IEA:UniProtKB-UniPathway.
DR   CDD; cd00332; PAL-HAL; 1.
DR   Gene3D; 1.10.275.10; -; 1.
DR   InterPro; IPR001106; Aromatic_Lyase.
DR   InterPro; IPR024083; Fumarase/histidase_N.
DR   InterPro; IPR008948; L-Aspartase-like.
DR   InterPro; IPR022313; Phe/His_NH3-lyase_AS.
DR   PANTHER; PTHR10362; PTHR10362; 1.
DR   Pfam; PF00221; Lyase_aromatic; 1.
DR   SUPFAM; SSF48557; SSF48557; 1.
DR   PROSITE; PS00488; PAL_HISTIDASE; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Histidine metabolism; Lyase; Reference proteome.
FT   CHAIN           1..529
FT                   /note="hal-like protein DDB_G0273787/DDB_G0273081"
FT                   /id="PRO_0000389023"
FT   MOD_RES         152
FT                   /note="2,3-didehydroalanine (Ser)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10122"
FT   CROSSLNK        151..153
FT                   /note="5-imidazolinone (Ala-Gly)"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   529 AA;  58568 MW;  DCB8EF3CEE11587B CRC64;
     MIETNHKDNF LIDGENKNLE INDIISISKG EKNIIFTNEL LEFLQKGRDQ LENKLKENVA
     IYGINTGFGG NGDLIIPFDK LDYHQSNLLD FLTCGTGDFF NDQYVRGIQF IIIIALSRGW
     SGVRPMVIQT LAKHLNKGII PQVPMHGSVG ASGDLVPLSY IANVLCGKGM VKYNEKLMNA
     SDALKITSIE PLVLKSKEGL ALVNGTRVMS SVSCISINKF ETIFKAAIGS IALAVEGLLA
     SKDHYDMRIH NLKNHPGQIL IAQILNKYFN TSDNNTKSSN ITFNQSENVQ KLDKSVQEVY
     SLRCAPQILG IISENISNAK IVIKREILSV NDNPLIDPYY GDVLSGGNFM GNHIARIMDG
     IKLDISLVAN HLHSLVALMM HSEFSKGLPN SLSPNPGIYQ GYKGMQISQT SLVVWLRQEA
     APACIHSLTT EQFNQDIVSL GLHSANGAAS MLIKLCDIVS MTLIIAFQAI SLRMKSIENF
     KLPNKVQKLY SSIIKIIPIL ENDRRTDIDV REITNAILQD KLDFINLNL