ID   HALCY_HALPP             Reviewed;          26 AA.
AC   P86415;
DT   19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT   19-JAN-2010, sequence version 1.
DT   25-MAY-2022, entry version 9.
DE   RecName: Full=Halocyntin {ECO:0000303|PubMed:19085906};
OS   Halocynthia papillosa (Red sea-squirt).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Stolidobranchia;
OC   Pyuridae; Halocynthia.
OX   NCBI_TaxID=201963;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, AND MASS SPECTROMETRY.
RC   TISSUE=Hemocyte {ECO:0000269|PubMed:19085906};
RX   PubMed=19085906; DOI=10.1002/psc.1101;
RA   Galinier R., Roger E., Sautiere P.E., Aumelas A., Banaigs B., Mitta G.;
RT   "Halocyntin and papillosin, two new antimicrobial peptides isolated from
RT   hemocytes of the solitary tunicate, Halocynthia papillosa.";
RL   J. Pept. Sci. 15:48-55(2009).
CC   -!- FUNCTION: Has strong antibacterial activity against the Gram-positive
CC       bacteria M.luteus, S.aureus, B.megaterium, A.viridans and E.faecalis,
CC       and against the Gram-negative bacterium K.pneumoniae. Has less potent
CC       antibacterial activity against the Gram-negative bacteria E.coli
CC       DH5alpha, S.typhimurium, P.aeruginosa, E.aerogenes and N.gonorrhoeae.
CC       Has moderate hemolytic activity against sheep erythrocytes.
CC       {ECO:0000269|PubMed:19085906}.
CC   -!- MASS SPECTROMETRY: Mass=2731.55; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:19085906};
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DR   AlphaFoldDB; P86415; -.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
DR   GO; GO:0044179; P:hemolysis in another organism; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Cytolysis; Direct protein sequencing; Hemolysis.
FT   PEPTIDE         1..26
FT                   /note="Halocyntin"
FT                   /evidence="ECO:0000269|PubMed:19085906"
FT                   /id="PRO_0000390783"
SQ   SEQUENCE   26 AA;  2733 MW;  AC6495FC0552E095 CRC64;
     FWGHIWNAVK RVGANALHGA VTGALS