HAL1_YEAST
ID HAL1_YEAST Reviewed; 294 AA.
AC Q01766; D6W416;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Halotolerance protein HAL1;
GN Name=HAL1; OrderedLocusNames=YPR005C; ORFNames=YP9723.05C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=DBY939;
RX PubMed=1505513; DOI=10.1002/j.1460-2075.1992.tb05392.x;
RA Gaxiola R., de Larrinoa I.F., Villalba J.M., Serrano R.;
RT "A novel and conserved salt-induced protein is an important determinant of
RT salt tolerance in yeast.";
RL EMBO J. 11:3157-3164(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169875;
RA Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D.,
RA Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E.,
RA Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H.,
RA DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N.,
RA Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K.,
RA Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M.,
RA Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A.,
RA Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S.,
RA Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R.,
RA Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A.,
RA Vo D.H., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL Nature 387:103-105(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-266, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19779198; DOI=10.1126/science.1172867;
RA Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT into evolution.";
RL Science 325:1682-1686(2009).
CC -!- FUNCTION: Involved in salt tolerance.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- INDUCTION: By salt stress.
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DR EMBL; U31900; AAA97584.1; -; Genomic_DNA.
DR EMBL; X67559; CAA47858.1; -; Genomic_DNA.
DR EMBL; Z48951; CAA88783.1; -; Genomic_DNA.
DR EMBL; Z71255; CAA95045.1; -; Genomic_DNA.
DR EMBL; BK006949; DAA11432.1; -; Genomic_DNA.
DR PIR; S23561; S23561.
DR RefSeq; NP_015330.1; NM_001184102.1.
DR AlphaFoldDB; Q01766; -.
DR BioGRID; 36182; 43.
DR IntAct; Q01766; 2.
DR MINT; Q01766; -.
DR STRING; 4932.YPR005C; -.
DR iPTMnet; Q01766; -.
DR PaxDb; Q01766; -.
DR PRIDE; Q01766; -.
DR EnsemblFungi; YPR005C_mRNA; YPR005C; YPR005C.
DR GeneID; 856113; -.
DR KEGG; sce:YPR005C; -.
DR SGD; S000006209; HAL1.
DR VEuPathDB; FungiDB:YPR005C; -.
DR HOGENOM; CLU_947154_0_0_1; -.
DR InParanoid; Q01766; -.
DR OMA; ENNCCKF; -.
DR BioCyc; YEAST:G3O-34167-MON; -.
DR PRO; PR:Q01766; -.
DR Proteomes; UP000002311; Chromosome XVI.
DR RNAct; Q01766; protein.
DR GO; GO:0005737; C:cytoplasm; IDA:SGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:SGD.
DR GO; GO:0009651; P:response to salt stress; IMP:SGD.
PE 1: Evidence at protein level;
KW Cytoplasm; Phosphoprotein; Reference proteome; Stress response.
FT CHAIN 1..294
FT /note="Halotolerance protein HAL1"
FT /id="PRO_0000083893"
FT REGION 115..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 266
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19779198"
SQ SEQUENCE 294 AA; 32994 MW; 85C4F35ADC1B78BF CRC64;
MHFKDLGLHD YTLKNLMYEN NCCKFYDAVD ENNISYVLKF VPSDVTSEGD TFPFVDRFQV
KEGVFLVYSS NDFGKEGTDY FTYTGSGGNE VHISGTSSEA GIKPQFIETC HPKHLKRGTK
EQEDINSSTS KKSAVINNFS GEKTPNPRPQ SSNISERETY VGILNVKCKN KNSSKIRSEK
LVSSVIETKH TPGLASILSK EGTTYPNNAD GKHISIVNPS SKIYHSSHKQ IVKTPIPKSG
LSPIERCPFN GQNIKCYSPR PLDHESPQRD FNNNFQLRIL KSSVLQRRQS TQNS
