HAK1_SCHOC
ID HAK1_SCHOC Reviewed; 821 AA.
AC P50505;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2001, sequence version 2.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=High affinity potassium transporter;
GN Name=HAK1;
OS Schwanniomyces occidentalis (Yeast) (Debaryomyces occidentalis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Schwanniomyces.
OX NCBI_TaxID=27300;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Rodriguez-Navarro A.;
RL Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 60-821.
RX PubMed=7621817; DOI=10.1002/j.1460-2075.1995.tb07304.x;
RA Banuelos M.A., Klein R.D., Alexander-Bowman S.J., Rodriguez-Navarro A.;
RT "A potassium transporter of the yeast Schwanniomyces occidentalis
RT homologous to the Kup system of Escherichia coli has a high concentrative
RT capacity.";
RL EMBO J. 14:3021-3027(1995).
CC -!- FUNCTION: Major high-affinity potassium uptake protein.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC {ECO:0000305}.
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DR EMBL; U22945; AAB17122.2; -; Genomic_DNA.
DR PIR; S56141; S56141.
DR AlphaFoldDB; P50505; -.
DR TCDB; 2.A.72.2.1; the k(+) uptake permease (kup) family.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR003855; K+_transporter.
DR PANTHER; PTHR30540; PTHR30540; 1.
DR Pfam; PF02705; K_trans; 1.
DR TIGRFAMs; TIGR00794; kup; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Ion transport; Membrane; Potassium; Potassium transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..821
FT /note="High affinity potassium transporter"
FT /id="PRO_0000209105"
FT TOPO_DOM 1..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..190
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 212..238
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 261..281
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 282..306
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..327
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 328..340
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 341..361
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 362..386
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 408..434
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 435..455
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 456..463
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 464..484
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 485..491
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 492..512
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 513..516
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 517..537
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 538..821
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 460
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 821 AA; 91935 MW; ECAEA760603F63C2 CRC64;
MSDSQSNKQN QGEDDNNVSS SIESNENYPF RLNDEESEPQ SSTTESMLKA KKQSWRQVLM
LGFSSLGAIY GDIGTSPLYV LNSIKYPNSS PTEEDIYGAI SIIFYLFTFI VIFKYILIVL
FLGTNDGEGG QVAIYAKIAR SLKIGPKGVH IPGSPEKTDL ELLARAETSS SFKSSNLFLN
KASGFKTNPK LIKFISKFIL FGCFFGCSLV MSDGLLTPTT SVLSAIAGIQ IANPSFNDVL
AVSEVVLIVL FLIQQFGSNK ISFTFAPIIF LWLIGLIISG IYNIVKFHPA VFKSLSPYYA
IQLLKHSGID VFSGAMLSIT GTEAMFADVG HFGRLPIQLT LTLFVYPALI ICYLGQGAYI
IKHPEALSNP FFYSIPGGLN SWIYWVMFVL ATLSTIIASQ ALILGVFSIT SQLINLDCFP
NFKIIHVSKK YAGKVYIPAI NWLLMIGVCA TTAGFKNSNN VTAAYGLGIT LDFLVTSSLI
MVCMTYVYNW NILIPITYAL IFLPLEVIMV ISNLKKITHG AWFPLMMSGI FMMFLSFWRW
ARSRKVNQDF KTRIRIGDLY PELKKQPPQS ETVDLNDRGR PMSIVNSSNE ELVEYGVTLP
KILKTNNNQL KVQSKFGLMN LKKYDGIAIM YNDSSVHTLN SPNTVPQVYG KLVSSFSSIP
SVFIFCSIRV LSIPTVPNDE RVLIGSMKIP GHYRCIIRYG FMEEILIDKE LNNHILNSIP
DINELAIKFN LNNKCILTKP CTIPILHIFE NNLIRSHDYS SEEHETKNPL VKCKRFIRKI
LINHIFSPIY SDFQSNGKFL KISDEDEESE KKMFLGGVVR I
