H4_SOLLC
ID H4_SOLLC Reviewed; 103 AA.
AC P35057;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Histone H4;
OS Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC Solanum subgen. Lycopersicon.
OX NCBI_TaxID=4081;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. VFNT Cherry; TISSUE=Shoot apex;
RX PubMed=7764315; DOI=10.1007/bf00198694;
RA Brandstaedter J.U., Rossbach C., Thers K.;
RT "The pattern of histone H4 expression in the tomato shoot apex changes
RT during development.";
RL Planta 192:69-74(1994).
CC -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC DNA into chromatin, limiting DNA accessibility to the cellular
CC machineries which require DNA as a template. Histones thereby play a
CC central role in transcription regulation, DNA repair, DNA replication
CC and chromosomal stability. DNA accessibility is regulated via a complex
CC set of post-translational modifications of histones, also called
CC histone code, and nucleosome remodeling.
CC -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC DNA.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the histone H4 family. {ECO:0000305}.
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DR EMBL; X69179; CAA48923.1; -; mRNA.
DR EMBL; X69180; CAA48924.1; -; mRNA.
DR PIR; S32769; S32769.
DR RefSeq; NP_001234118.1; NM_001247189.1.
DR RefSeq; NP_001234121.1; NM_001247192.2.
DR RefSeq; XP_004239779.1; XM_004239731.3.
DR RefSeq; XP_004241478.1; XM_004241430.3.
DR RefSeq; XP_004251292.1; XM_004251244.3.
DR AlphaFoldDB; P35057; -.
DR SMR; P35057; -.
DR STRING; 4081.Solyc04g011390.1.1; -.
DR PaxDb; P35057; -.
DR EnsemblPlants; Solyc04g011390.1.1; Solyc04g011390.1.1.1; Solyc04g011390.1.
DR EnsemblPlants; Solyc05g054610.1.1; Solyc05g054610.1.1.1; Solyc05g054610.1.
DR EnsemblPlants; Solyc06g005420.1.1; Solyc06g005420.1.1.1; Solyc06g005420.1.
DR EnsemblPlants; Solyc06g005430.1.1; Solyc06g005430.1.1.1; Solyc06g005430.1.
DR EnsemblPlants; Solyc06g072240.1.1; Solyc06g072240.1.1.1; Solyc06g072240.1.
DR EnsemblPlants; Solyc06g075830.2.1; Solyc06g075830.2.1; Solyc06g075830.2.
DR EnsemblPlants; Solyc06g075930.1.1; Solyc06g075930.1.1.1; Solyc06g075930.1.
DR EnsemblPlants; Solyc06g075960.1.1; Solyc06g075960.1.1.1; Solyc06g075960.1.
DR EnsemblPlants; Solyc11g072860.2.1; Solyc11g072860.2.1.1; Solyc11g072860.2.
DR GeneID; 101248209; -.
DR GeneID; 101256941; -.
DR GeneID; 101260642; -.
DR GeneID; 544080; -.
DR GeneID; 544081; -.
DR Gramene; Solyc04g011390.1.1; Solyc04g011390.1.1.1; Solyc04g011390.1.
DR Gramene; Solyc05g054610.1.1; Solyc05g054610.1.1.1; Solyc05g054610.1.
DR Gramene; Solyc06g005420.1.1; Solyc06g005420.1.1.1; Solyc06g005420.1.
DR Gramene; Solyc06g005430.1.1; Solyc06g005430.1.1.1; Solyc06g005430.1.
DR Gramene; Solyc06g072240.1.1; Solyc06g072240.1.1.1; Solyc06g072240.1.
DR Gramene; Solyc06g075830.2.1; Solyc06g075830.2.1; Solyc06g075830.2.
DR Gramene; Solyc06g075930.1.1; Solyc06g075930.1.1.1; Solyc06g075930.1.
DR Gramene; Solyc06g075960.1.1; Solyc06g075960.1.1.1; Solyc06g075960.1.
DR Gramene; Solyc11g072860.2.1; Solyc11g072860.2.1.1; Solyc11g072860.2.
DR KEGG; sly:101248209; -.
DR KEGG; sly:101256941; -.
DR KEGG; sly:101260642; -.
DR KEGG; sly:544080; -.
DR KEGG; sly:544081; -.
DR eggNOG; KOG3467; Eukaryota.
DR HOGENOM; CLU_109117_2_3_1; -.
DR InParanoid; P35057; -.
DR OrthoDB; 1564596at2759; -.
DR PhylomeDB; P35057; -.
DR Proteomes; UP000004994; Chromosome 11.
DR Proteomes; UP000004994; Chromosome 4.
DR Proteomes; UP000004994; Chromosome 5.
DR Proteomes; UP000004994; Chromosome 6.
DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0006334; P:nucleosome assembly; IBA:GO_Central.
DR CDD; cd00076; H4; 1.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR035425; CENP-T/H4_C.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR001951; Histone_H4.
DR InterPro; IPR019809; Histone_H4_CS.
DR Pfam; PF15511; CENP-T_C; 1.
DR PRINTS; PR00623; HISTONEH4.
DR SMART; SM00417; H4; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
DR PROSITE; PS00047; HISTONE_H4; 1.
PE 3: Inferred from homology;
KW Acetylation; Chromosome; DNA-binding; Nucleosome core; Nucleus;
KW Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..103
FT /note="Histone H4"
FT /id="PRO_0000158322"
FT DNA_BIND 17..21
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250"
FT MOD_RES 6
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250"
FT MOD_RES 9
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250"
FT MOD_RES 13
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250"
FT MOD_RES 17
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250"
FT MOD_RES 21
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 103 AA; 11425 MW; A9E4B0EC3A2A7598 CRC64;
MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL IYEETRGVLK
IFLENVIRDS VTYTEHARRK TVTAMDVVYA LKRQGRTLYG FGG
