GVQW3_HUMAN
ID GVQW3_HUMAN Reviewed; 254 AA.
AC Q3ZCU0; Q8N9C3;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Protein GVQW3 {ECO:0000305};
DE AltName: Full=GVQW motif-containing protein 3 {ECO:0000305};
GN Name=GVQW3 {ECO:0000312|HGNC:HGNC:51239};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Hippocampus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3ZCU0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3ZCU0-2; Sequence=VSP_031695, VSP_031696;
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DR EMBL; AK095089; BAC04485.1; -; mRNA.
DR EMBL; AP002360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC040665; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS73348.1; -. [Q3ZCU0-1]
DR CCDS; CCDS81599.1; -. [Q3ZCU0-2]
DR RefSeq; NP_001269385.1; NM_001282456.3. [Q3ZCU0-1]
DR RefSeq; NP_001292154.1; NM_001305225.2. [Q3ZCU0-2]
DR AlphaFoldDB; Q3ZCU0; -.
DR SMR; Q3ZCU0; -.
DR BioGRID; 132445; 1.
DR iPTMnet; Q3ZCU0; -.
DR PhosphoSitePlus; Q3ZCU0; -.
DR BioMuta; -; -.
DR DMDM; 121943108; -.
DR jPOST; Q3ZCU0; -.
DR PaxDb; Q3ZCU0; -.
DR PeptideAtlas; Q3ZCU0; -.
DR PRIDE; Q3ZCU0; -.
DR Antibodypedia; 71842; 4 antibodies from 4 providers.
DR DNASU; 100506127; -.
DR Ensembl; ENST00000321844.6; ENSP00000323821.4; ENSG00000179240.13. [Q3ZCU0-1]
DR Ensembl; ENST00000530460.2; ENSP00000489606.1; ENSG00000179240.13. [Q3ZCU0-2]
DR Ensembl; ENST00000607673.2; ENSP00000499448.1; ENSG00000179240.13. [Q3ZCU0-2]
DR Ensembl; ENST00000663165.1; ENSP00000499610.1; ENSG00000179240.13. [Q3ZCU0-2]
DR GeneID; 100506127; -.
DR KEGG; hsa:100506127; -.
DR UCSC; uc031xvt.2; human. [Q3ZCU0-1]
DR CTD; 100506127; -.
DR DisGeNET; 100506127; -.
DR GeneCards; GVQW3; -.
DR HGNC; HGNC:51239; GVQW3.
DR HPA; ENSG00000179240; Tissue enhanced (retina).
DR neXtProt; NX_Q3ZCU0; -.
DR VEuPathDB; HostDB:ENSG00000179240; -.
DR eggNOG; ENOG502S5UP; Eukaryota.
DR GeneTree; ENSGT00440000033232; -.
DR HOGENOM; CLU_1098209_0_0_1; -.
DR OrthoDB; 1052926at2759; -.
DR PhylomeDB; Q3ZCU0; -.
DR BioGRID-ORCS; 100506127; 0 hits in 53 CRISPR screens.
DR ChiTaRS; GVQW3; human.
DR GenomeRNAi; 100506127; -.
DR Pharos; Q3ZCU0; Tdark.
DR PRO; PR:Q3ZCU0; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q3ZCU0; protein.
DR Bgee; ENSG00000179240; Expressed in cortical plate and 131 other tissues.
DR ExpressionAtlas; Q3ZCU0; baseline and differential.
DR Genevisible; Q3ZCU0; HS.
DR InterPro; IPR041426; Mos1_HTH.
DR Pfam; PF17906; HTH_48; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..254
FT /note="Protein GVQW3"
FT /id="PRO_0000320634"
FT VAR_SEQ 128..210
FT /note="ETEPHYVAQAGLELLVSRDPPTLASQSSGIISMSHHAKPKPGVQWCKFQSES
FT TGRRARSADVQGQEKMDVTAQEARTNLPFYL -> GEPKPRKLDFRSDLSKETRKNSSC
FT LRKKVTGSETWSYLQGEAGGEMPLPVSHPRVHYSASQLLQASSSTSLPPRVAENWFTPW
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_031695"
FT VAR_SEQ 211..254
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_031696"
SQ SEQUENCE 254 AA; 29382 MW; EE8CA4EA3FD3A0E4 CRC64;
MSDRYLEQRI SIKFCVKLNK SASETHHLLK EAYGDEVMSR ARVFDWHKRF KEGREDVRDD
ARSGRPVTHR TDDNIQKVKD LVCSNRQLTV RMMAEELNLD KETVRLILKE NLNMRKISAK
VISGVLKETE PHYVAQAGLE LLVSRDPPTL ASQSSGIISM SHHAKPKPGV QWCKFQSEST
GRRARSADVQ GQEKMDVTAQ EARTNLPFYL FVLFRSSMNW MMSMHIREGC LFITRSTNSN
ANLFRKHPHR HTQK
