ID   GRTP1_XENLA             Reviewed;         342 AA.
AC   Q6GLZ0;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Growth hormone-regulated TBC protein 1;
GN   Name=grtp1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a GTPase-activating protein for Rab family
CC       protein(s).
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DR   EMBL; BC074303; AAH74303.1; -; mRNA.
DR   RefSeq; NP_001086187.1; NM_001092718.1.
DR   AlphaFoldDB; Q6GLZ0; -.
DR   SMR; Q6GLZ0; -.
DR   DNASU; 444616; -.
DR   GeneID; 444616; -.
DR   KEGG; xla:444616; -.
DR   CTD; 444616; -.
DR   Xenbase; XB-GENE-950231; grtp1.S.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 444616; Expressed in camera-type eye and 18 other tissues.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR   InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF47923; SSF47923; 2.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   2: Evidence at transcript level;
KW   GTPase activation; Reference proteome.
FT   CHAIN           1..342
FT                   /note="Growth hormone-regulated TBC protein 1"
FT                   /id="PRO_0000288712"
FT   DOMAIN          72..263
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
SQ   SEQUENCE   342 AA;  39678 MW;  F8FEE690C0AC53F9 CRC64;
     MDEANQIAKD SVPRIDAYGF IRPVEFDYAV YEEFIARYRV VLTRRALKWS KLLQQSAAVE
     KSIKVKRYIR KGIPNEHRSH VWMVVSGAQA QMGMNTGYFR RMFIEGEKNP KLLDLVNTDL
     NRTFPDNVQF RKNSNPSLQK HLYNVLVAYG QHNTTVGYCQ GMNFIAGYLI LVTKDEEKAF
     WLMDALIGRI LPDYYSPAMT GLKTDQEVLG DLVKKKLPAV SQLIEAHGVM WTLLVSRWFI
     CLFIDILPVE TVLRIWDCLF FEGSKVLFRV ALTLIKQYQA FILEARNFPD ICDKFKEITK
     GEFVTDCHYF MQKIFAEPGS LSKTTIDKLR EKQRLQLASE EK