ID   GRPA_RAT                Reviewed;         246 AA.
AC   P08568;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 3.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Submandibular gland secretory Glx-rich protein CA;
DE            Short=GRP-CA;
DE   Flags: Precursor;
GN   Name=Grpca;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar;
RX   PubMed=1995617; DOI=10.1016/s0021-9258(19)67828-2;
RA   Cooper L.F., Elia D.M., Tabak L.A.;
RT   "Secretagogue-coupled changes in the expression of glutamine/glutamic acid-
RT   rich proteins (GRPs). Isoproterenol induces changes in GRP transcript
RT   expression and changes in isoforms secreted.";
RL   J. Biol. Chem. 266:3532-3539(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 17-246.
RX   PubMed=2438276; DOI=10.1016/s0021-9258(18)48235-x;
RA   Mirels L., Bedi G.S., Dickinson D.P., Gross K.W., Tabak L.A.;
RT   "Molecular characterization of glutamic acid/glutamine-rich secretory
RT   proteins from rat submandibular glands.";
RL   J. Biol. Chem. 262:7289-7297(1987).
CC   -!- FUNCTION: GRP proteins have a marked affinity for hydroxyapatite. They
CC       may play a role in the formation of the protective acquired pellicle at
CC       the saliva-tooth interface.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Submandibular gland acinar cells.
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DR   EMBL; M58653; AAA41278.1; -; mRNA.
DR   EMBL; J02730; AAA41276.1; -; mRNA.
DR   PIR; A29573; A29573.
DR   PIR; A38647; A38647.
DR   AlphaFoldDB; P08568; -.
DR   SMR; P08568; -.
DR   RGD; 619775; Grpca.
DR   PhylomeDB; P08568; -.
DR   PRO; PR:P08568; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0046848; F:hydroxyapatite binding; IDA:RGD.
DR   GO; GO:0031214; P:biomineral tissue development; IEA:UniProtKB-KW.
DR   InterPro; IPR026086; Pro-rich.
DR   PANTHER; PTHR23203; PTHR23203; 4.
DR   Pfam; PF15240; Pro-rich; 1.
DR   SMART; SM01412; Pro-rich; 1.
PE   2: Evidence at transcript level;
KW   Biomineralization; Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..18
FT   CHAIN           19..246
FT                   /note="Submandibular gland secretory Glx-rich protein CA"
FT                   /id="PRO_0000013038"
FT   REPEAT          67..89
FT                   /note="1"
FT   REPEAT          90..112
FT                   /note="2"
FT   REPEAT          113..135
FT                   /note="3"
FT   REPEAT          136..158
FT                   /note="4"
FT   REPEAT          159..181
FT                   /note="5"
FT   REGION          14..223
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          67..181
FT                   /note="5 X 23 AA tandem repeats"
FT   COMPBIAS        14..44
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        72..196
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        202..216
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        63
FT                   /note="A -> P (in Ref. 2; AAA41276)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        135
FT                   /note="D -> N (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        137
FT                   /note="Q -> E (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        208
FT                   /note="E -> D (in Ref. 2; AAA41276)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        230
FT                   /note="R -> P (in Ref. 2; AAA41276)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   246 AA;  26528 MW;  1C7144CFE67375AA CRC64;
     MLVVLLTAAL LALSSAQGTD EEVNNAETSD VPADSEQQPV DSGSDPPSAD ADAENVQEGE
     SAAPANEEPP ATSGSEEEQQ QQEPTQAENQ EPPATSGSEE EQQQQEPTQA ENQEPPATSG
     SEEEQQQQEP TQAEDQQPPA TSGSEEEQQQ QESTQAENQE PSDSAGEGQE TQPEEGNVES
     PPSSPENSQE QPQQTNPEEK PPAPKTQEEP QHDSGRPKKP LLPFIANLIR ERIRKLLARS
     PLGRRF