GRLK_DICDI
ID GRLK_DICDI Reviewed; 704 AA.
AC Q1ZXQ7;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Metabotropic glutamate receptor-like protein K;
DE Flags: Precursor;
GN Name=grlK; ORFNames=DDB_G0269386;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NOMENCLATURE.
RX PubMed=16735079; DOI=10.1016/j.ejcb.2006.04.003;
RA Prabhu Y., Eichinger L.;
RT "The Dictyostelium repertoire of seven transmembrane domain receptors.";
RL Eur. J. Cell Biol. 85:937-946(2006).
RN [3]
RP DEVELOPMENTAL STAGE.
RX PubMed=17501984; DOI=10.1186/1471-213x-7-44;
RA Prabhu Y., Mueller R., Anjard C., Noegel A.A.;
RT "GrlJ, a Dictyostelium GABAB-like receptor with roles in post-aggregation
RT development.";
RL BMC Dev. Biol. 7:44-44(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Increased levels found from the tight aggregation
CC stage onward. Levels stayed high during late development. Clear
CC expression at 24 hours when fruiting body formation is close to
CC completion. {ECO:0000269|PubMed:17501984}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the BMP lipoprotein
CC family. {ECO:0000305}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the G-protein coupled
CC receptor 3 family. GABA-B receptor subfamily. {ECO:0000305}.
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DR EMBL; AAFI02000005; EAS66931.1; -; Genomic_DNA.
DR RefSeq; XP_001134467.1; XM_001134467.1.
DR AlphaFoldDB; Q1ZXQ7; -.
DR SMR; Q1ZXQ7; -.
DR PaxDb; Q1ZXQ7; -.
DR EnsemblProtists; EAS66931; EAS66931; DDB_G0269386.
DR GeneID; 8616865; -.
DR KEGG; ddi:DDB_G0269386; -.
DR dictyBase; DDB_G0269386; grlK.
DR eggNOG; KOG1055; Eukaryota.
DR HOGENOM; CLU_365408_0_0_1; -.
DR InParanoid; Q1ZXQ7; -.
DR PhylomeDB; Q1ZXQ7; -.
DR PRO; PR:Q1ZXQ7; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR003760; PnrA-like.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF02608; Bmp; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Signal; Transducer; Transmembrane; Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..704
FT /note="Metabotropic glutamate receptor-like protein K"
FT /id="PRO_0000370354"
FT TOPO_DOM 22..383
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 384..404
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 405..419
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 420..440
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 441..455
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 456..476
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 477..492
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 493..513
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 514..541
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 542..562
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 563..578
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 579..599
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 600..608
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 609..629
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 630..704
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 657..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 685..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 66
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 104
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 256
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 286
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 308
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 337
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 343
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 368
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 538
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 704 AA; 78365 MW; 957D765F7607FFD7 CRC64;
MIKLILSIIL IICFIINSIE SFKMITLTTG PPSDLGWNNM INLGRIGVTK AMDIEDSRLF
VVSGRNDTYE LLLPIIQNDD IDLVICSSLD HGDACKEIAA MYVNSTEIKT QFLVRGSGAT
TKNLIQFTYN YASVNYLSGM FAGLQTKTNK IGFISPGITA GASDCFVYAF WLGAKSVNPN
IKFYYYNIGS YLDKDKTKGA AENLIDVYDC DVIGDTLDDF TASNVAISRG RYAIGTNGFP
QRDVYGENVV YTYAYNWTKY FVPIASAVKN KIPPSKWYAD FNKDNNLSLY DLSFGFQVSA
ETKFKIINQT KSFASYVRTL HPYFCNEYME GYTQKYNLTR QPNTTNCITT TGFIGIDAPV
GDMNYLGNYT IKFSKVEFQR SIQIGFSIVS GLLIGFVILM MIGIVKYQDT PSIRSASPSF
LNLTLLGGVI IFIGIIVWVA PISTHQCNAR FWLVTIGFST LIGSLVVKNI RIWLIFDNPE
LKIRTITNNQ LYPWVGLCLV INIVLMSIIT TVGDLKAIEA QGIDSLGKFE YMTICKMNYT
GAATLYSILA YFGTLLLVGV FVSWKIRIVH IEEFSECTAI AKTLYSISFC LFVIVPLMIS
PQDKQSETII LCVTGIFITT GALLIFFLPK FWRIFGNEKQ GSHEHFTQRK QSAVASARAE
SANRNNSSNS FGFSKSSAQI GNTISGIESL NDDSNESSLS NETK
