ID   GRA5_TOXGO              Reviewed;         120 AA.
AC   Q07828;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Dense granule protein 5;
DE            Short=Protein GRA 5;
DE   AltName: Full=p21;
DE   Flags: Precursor;
GN   Name=GRA5;
OS   Toxoplasma gondii.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC   Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.
OX   NCBI_TaxID=5811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 30-42; 45-63;
RP   66-74 AND 100-113.
RC   STRAIN=RH; TISSUE=Tachyzoite;
RX   PubMed=8515776; DOI=10.1016/0166-6851(93)90015-p;
RA   Lecordier L., Mercier C., Torpier G., Tourvieille B., Darcy F., Liu J.-L.,
RA   Maes P., Tartar A., Capron A., Cesbron-Delauw M.-F.;
RT   "Molecular structure of a Toxoplasma gondii dense granule antigen (GRA 5)
RT   associated with the parasitophorous vacuole membrane.";
RL   Mol. Biochem. Parasitol. 59:143-154(1993).
RN   [2]
RP   SEQUENCE REVISION TO C-TERMINUS.
RA   Lecordier L.;
RL   Submitted (JUL-1997) to UniProtKB.
CC   -!- FUNCTION: Plays a role in the function of the cyst and parasitophorous
CC       vacuole membranes and therefore in host-parasite interactions.
CC   -!- SUBCELLULAR LOCATION: Secreted. Parasitophorous vacuole lumen.
CC       Parasitophorous vacuole membrane. Cytoplasmic vesicle, secretory
CC       vesicle. Note=Located in dense granules of tachyzoites. Upon infection,
CC       secreted into the cyst and the parasitophorous vacuole (PV).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L06091; AAB63601.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q07828; -.
DR   SMR; Q07828; -.
DR   VEuPathDB; ToxoDB:TGCAST_286450; -.
DR   VEuPathDB; ToxoDB:TGFOU_286450; -.
DR   VEuPathDB; ToxoDB:TGGT1_286450; -.
DR   VEuPathDB; ToxoDB:TGRH88_025740; -.
DR   VEuPathDB; ToxoDB:TGVAND_286450; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0020005; C:symbiont-containing vacuole membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Cytoplasmic vesicle; Direct protein sequencing; Membrane; Secreted; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..120
FT                   /note="Dense granule protein 5"
FT                   /id="PRO_0000021370"
FT   TRANSMEM        76..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          27..59
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          100..120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   120 AA;  12977 MW;  ACE4745D280C4A51 CRC64;
     MASVKRVVVA VMIVNVLALI FVGVAGSTRD VGSGGDDSEG ARGREQQQVQ QHEQNEDRSL
     FERGRAAVTG HPVRTAVGLA AAVVAVVSLL RLLKRRRRRA IQEESKESAT AEEEEVAEEE