ID   GPX8_BOVIN              Reviewed;         209 AA.
AC   Q2NL01;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Probable glutathione peroxidase 8;
DE            Short=GPx-8;
DE            Short=GSHPx-8;
DE            EC=1.11.1.9;
GN   Name=GPX8;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 glutathione + H2O2 = glutathione disulfide + 2 H2O;
CC         Xref=Rhea:RHEA:16833, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240,
CC         ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.11.1.9;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the glutathione peroxidase family.
CC       {ECO:0000305}.
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DR   EMBL; BC111287; AAI11288.1; -; mRNA.
DR   RefSeq; NP_001039553.1; NM_001046088.2.
DR   AlphaFoldDB; Q2NL01; -.
DR   SMR; Q2NL01; -.
DR   STRING; 9913.ENSBTAP00000029279; -.
DR   PaxDb; Q2NL01; -.
DR   PRIDE; Q2NL01; -.
DR   Ensembl; ENSBTAT00000029279; ENSBTAP00000029279; ENSBTAG00000021960.
DR   GeneID; 511575; -.
DR   KEGG; bta:511575; -.
DR   CTD; 493869; -.
DR   VEuPathDB; HostDB:ENSBTAG00000021960; -.
DR   eggNOG; KOG1651; Eukaryota.
DR   GeneTree; ENSGT00940000159371; -.
DR   HOGENOM; CLU_029507_0_1_1; -.
DR   InParanoid; Q2NL01; -.
DR   OMA; KVVRFWR; -.
DR   OrthoDB; 1483113at2759; -.
DR   TreeFam; TF331942; -.
DR   Proteomes; UP000009136; Chromosome 20.
DR   Bgee; ENSBTAG00000021960; Expressed in caput epididymis and 102 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004602; F:glutathione peroxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004601; F:peroxidase activity; IBA:GO_Central.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   CDD; cd00340; GSH_Peroxidase; 1.
DR   InterPro; IPR013376; Glut_perox_Gpx7.
DR   InterPro; IPR000889; Glutathione_peroxidase.
DR   InterPro; IPR029760; GPX_CS.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR11592; PTHR11592; 1.
DR   Pfam; PF00255; GSHPx; 1.
DR   PIRSF; PIRSF000303; Glutathion_perox; 1.
DR   PRINTS; PR01011; GLUTPROXDASE.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   TIGRFAMs; TIGR02540; gpx7; 1.
DR   PROSITE; PS00763; GLUTATHIONE_PEROXID_2; 1.
DR   PROSITE; PS51355; GLUTATHIONE_PEROXID_3; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Membrane; Oxidoreductase; Peroxidase; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..209
FT                   /note="Probable glutathione peroxidase 8"
FT                   /id="PRO_0000317755"
FT   TRANSMEM        18..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        79
FT                   /evidence="ECO:0000250"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TED1"
SQ   SEQUENCE   209 AA;  23983 MW;  3A26DF87DBA34B3B CRC64;
     MEPLTAYPLR CSGPKAKAFA VLLSMVLCTV MLFLLQLKFL KPKINSFYTF EVKDANGRVV
     SLEKFKGKVA LVVNVASDCQ LTDRNYLALQ ELHKEFGPFH FSVLAFPCNQ FGESEPRPSK
     EVVSFARNNF GVTFPIFHKI KILGSEAEPA FRFLVDSSKK EPRWNFWKYL VNPEGQVVKT
     WRPEEPIEVI RPEIAALIRQ MIIKKKEDL