GPT11_MOUSE
ID GPT11_MOUSE Reviewed; 262 AA.
AC Q3UFS4; B9EHQ5; Q05BG4; Q569F3;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 2.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=G patch domain-containing protein 11;
DE AltName: Full=Coiled-coil domain-containing protein 75;
GN Name=Gpatch11; Synonyms=Ccdc75;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, Eye, and Limb;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000250|UniProtKB:Q8N954}.
CC -!- SIMILARITY: Belongs to the GPATCH11 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH47998.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH92522.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI38311.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAE28486.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK148331; BAE28486.1; ALT_INIT; mRNA.
DR EMBL; BC047998; AAH47998.1; ALT_INIT; mRNA.
DR EMBL; BC092522; AAH92522.1; ALT_INIT; mRNA.
DR EMBL; BC138310; AAI38311.1; ALT_INIT; mRNA.
DR RefSeq; NP_857632.4; NM_181649.6.
DR RefSeq; XP_006524686.1; XM_006524623.3.
DR AlphaFoldDB; Q3UFS4; -.
DR STRING; 10090.ENSMUSP00000126814; -.
DR iPTMnet; Q3UFS4; -.
DR PhosphoSitePlus; Q3UFS4; -.
DR EPD; Q3UFS4; -.
DR MaxQB; Q3UFS4; -.
DR PaxDb; Q3UFS4; -.
DR PeptideAtlas; Q3UFS4; -.
DR PRIDE; Q3UFS4; -.
DR ProteomicsDB; 271154; -.
DR DNASU; 53951; -.
DR GeneID; 53951; -.
DR KEGG; mmu:53951; -.
DR UCSC; uc008dpf.2; mouse.
DR CTD; 253635; -.
DR MGI; MGI:1858435; Gpatch11.
DR eggNOG; KOG1994; Eukaryota.
DR InParanoid; Q3UFS4; -.
DR OrthoDB; 1277915at2759; -.
DR PhylomeDB; Q3UFS4; -.
DR TreeFam; TF313583; -.
DR BioGRID-ORCS; 53951; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q3UFS4; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q3UFS4; protein.
DR GO; GO:0000776; C:kinetochore; ISS:UniProtKB.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR InterPro; IPR025239; DUF4187.
DR InterPro; IPR000467; G_patch_dom.
DR InterPro; IPR039249; GPATCH11.
DR PANTHER; PTHR21032; PTHR21032; 1.
DR Pfam; PF13821; DUF4187; 1.
DR Pfam; PF01585; G-patch; 1.
DR SMART; SM01173; DUF4187; 1.
DR SMART; SM00443; G_patch; 1.
DR PROSITE; PS50174; G_PATCH; 1.
PE 1: Evidence at protein level;
KW Centromere; Chromosome; Coiled coil; Kinetochore; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..262
FT /note="G patch domain-containing protein 11"
FT /id="PRO_0000279753"
FT DOMAIN 69..115
FT /note="G-patch"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 189..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 28..61
FT /evidence="ECO:0000255"
FT COMPBIAS 27..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..214
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 115
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N954"
FT CONFLICT 200..201
FT /note="Missing (in Ref. 2; AAH92522)"
FT /evidence="ECO:0000305"
FT CONFLICT 247
FT /note="E -> K (in Ref. 2; AAH47998)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 262 AA; 30608 MW; 9E5634969FAB01AB CRC64;
MTEEEDYMSD SFINVQEDVR PGVPMLRQIR EARRKEEKQQ QANLRNRQKS VKEEERERRD
IGLKNALGCE NKGFALLQKM GYKSGQALGK SGDGIVEPIP LNVKTGKSGI GHESSLKRKA
EERLENYRRK IHMKNQNEAK AAEEFRMRLK SKQDEMRLEG DLRRSQRACQ QLDAQKNIQV
PREAWYWLRP EEETEEEEEE EEKEEQDEDE CPSEDLSVLE KLQILTGYLR EEHLYCIWCG
TAYEDKEDLS SNCPGPTSAD HD
