ID   GPSM3_RAT               Reviewed;         158 AA.
AC   Q6MG88;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=G-protein-signaling modulator 3;
GN   Name=Gpsm3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15060004; DOI=10.1101/gr.1987704;
RA   Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H.,
RA   Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.;
RT   "The genomic sequence and comparative analysis of the rat major
RT   histocompatibility complex.";
RL   Genome Res. 14:631-639(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Thymus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: Interacts with subunit of G(i) alpha proteins and regulates
CC       the activation of G(i) alpha proteins. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The GoLoco 1 and/or GoLoco 3 domains exhibit GDI activity
CC       towards GDP-bound G(i) alpha protein, but not the GoLoco 2 domain.
CC       {ECO:0000250}.
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DR   EMBL; BX883044; CAE83958.1; -; Genomic_DNA.
DR   EMBL; BC088220; AAH88220.1; -; mRNA.
DR   RefSeq; NP_001003974.1; NM_001003974.2.
DR   AlphaFoldDB; Q6MG88; -.
DR   STRING; 10116.ENSRNOP00000000510; -.
DR   iPTMnet; Q6MG88; -.
DR   PhosphoSitePlus; Q6MG88; -.
DR   PaxDb; Q6MG88; -.
DR   Ensembl; ENSRNOT00000000510; ENSRNOP00000000510; ENSRNOG00000000441.
DR   GeneID; 406163; -.
DR   KEGG; rno:406163; -.
DR   UCSC; RGD:1303014; rat.
DR   CTD; 63940; -.
DR   RGD; 1303014; Gpsm3.
DR   eggNOG; ENOG502STIS; Eukaryota.
DR   GeneTree; ENSGT00390000002471; -.
DR   HOGENOM; CLU_139851_0_0_1; -.
DR   InParanoid; Q6MG88; -.
DR   OMA; HQSQRME; -.
DR   OrthoDB; 1581870at2759; -.
DR   PhylomeDB; Q6MG88; -.
DR   TreeFam; TF339136; -.
DR   Reactome; R-RNO-418594; G alpha (i) signalling events.
DR   PRO; PR:Q6MG88; -.
DR   Proteomes; UP000002494; Chromosome 20.
DR   Bgee; ENSRNOG00000000441; Expressed in thymus and 18 other tissues.
DR   Genevisible; Q6MG88; RN.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR   GO; GO:0030695; F:GTPase regulator activity; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; TAS:RGD.
DR   GO; GO:1900017; P:positive regulation of cytokine production involved in inflammatory response; ISO:RGD.
DR   GO; GO:0050729; P:positive regulation of inflammatory response; ISO:RGD.
DR   GO; GO:0002690; P:positive regulation of leukocyte chemotaxis; ISO:RGD.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR003109; GoLoco_motif.
DR   InterPro; IPR042888; GPSM3.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR47617; PTHR47617; 1.
DR   Pfam; PF02188; GoLoco; 2.
DR   SMART; SM00390; GoLoco; 3.
DR   PROSITE; PS50877; GOLOCO; 2.
PE   1: Evidence at protein level;
KW   Cytoplasm; Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..158
FT                   /note="G-protein-signaling modulator 3"
FT                   /id="PRO_0000233719"
FT   DOMAIN          60..82
FT                   /note="GoLoco 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00097"
FT   DOMAIN          102..124
FT                   /note="GoLoco 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00097"
FT   DOMAIN          130..153
FT                   /note="GoLoco 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00097"
FT   REGION          1..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          78..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         33
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y4H4"
FT   MOD_RES         37
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y4H4"
FT   MOD_RES         54
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3U1Z5"
FT   MOD_RES         57
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y4H4"
FT   MOD_RES         60
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y4H4"
SQ   SEQUENCE   158 AA;  17492 MW;  7F57D45BB11348FF CRC64;
     MEAERPQEDG EQSLPQDDQG WPPVNSTARP WRSAPPSPPP PGTRHTALGP RSGSLLSLQT
     ELLLDLVAEA QSRRLEEQRA AFHTPKVPPS LAPTPPRLLE DKEQLYSTIL SHQCQRIEAQ
     RSDPPLPPGG QELLELLLRV QGGGRMEDQR SRPPTHTC