GNGF_STRPN
ID GNGF_STRPN Reviewed; 325 AA.
AC Q97PN8;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Putative gluconeogenesis factor {ECO:0000255|HAMAP-Rule:MF_00973};
GN OrderedLocusNames=SP_1565;
OS Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=170187;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-334 / TIGR4;
RX PubMed=11463916; DOI=10.1126/science.1061217;
RA Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT "Complete genome sequence of a virulent isolate of Streptococcus
RT pneumoniae.";
RL Science 293:498-506(2001).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS).
RC STRAIN=ATCC BAA-334 / TIGR4;
RG Joint Center for Structural Genomics (JCSG);
RT "Crystal structure of uncharacterized protein SP_1565 (NP_346012.1) from
RT Streptococcus pneumoniae TIGR4 at 2.00 A resolution.";
RL Submitted (JUN-2007) to the PDB data bank.
CC -!- FUNCTION: Required for morphogenesis under gluconeogenic growth
CC conditions. {ECO:0000255|HAMAP-Rule:MF_00973}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00973}.
CC -!- SIMILARITY: Belongs to the gluconeogenesis factor family.
CC {ECO:0000255|HAMAP-Rule:MF_00973}.
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DR EMBL; AE005672; AAK75652.1; -; Genomic_DNA.
DR PIR; C95182; C95182.
DR RefSeq; WP_001231105.1; NZ_AKVY01000001.1.
DR PDB; 2Q7X; X-ray; 2.00 A; A/B=1-325.
DR PDBsum; 2Q7X; -.
DR AlphaFoldDB; Q97PN8; -.
DR SMR; Q97PN8; -.
DR STRING; 170187.SP_1565; -.
DR DNASU; 931275; -.
DR EnsemblBacteria; AAK75652; AAK75652; SP_1565.
DR KEGG; spn:SP_1565; -.
DR eggNOG; COG0391; Bacteria.
DR OMA; LCGDDDW; -.
DR PhylomeDB; Q97PN8; -.
DR BioCyc; SPNE170187:G1FZB-1584-MON; -.
DR EvolutionaryTrace; Q97PN8; -.
DR Proteomes; UP000000585; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0043743; F:LPPG:FO 2-phospho-L-lactate transferase activity; IEA:InterPro.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.10680; -; 1.
DR HAMAP; MF_00973; Gluconeogen_factor; 1.
DR InterPro; IPR002882; CofD.
DR InterPro; IPR038136; CofD-like_dom_sf.
DR InterPro; IPR010119; Gluconeogen_factor.
DR PANTHER; PTHR30135; PTHR30135; 1.
DR Pfam; PF01933; CofD; 1.
DR SUPFAM; SSF142338; SSF142338; 1.
DR TIGRFAMs; TIGR01826; CofD_related; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm.
FT CHAIN 1..325
FT /note="Putative gluconeogenesis factor"
FT /id="PRO_0000107813"
FT STRAND 6..9
FT /evidence="ECO:0007829|PDB:2Q7X"
FT HELIX 15..24
FT /evidence="ECO:0007829|PDB:2Q7X"
FT STRAND 30..33
FT /evidence="ECO:0007829|PDB:2Q7X"
FT HELIX 39..42
FT /evidence="ECO:0007829|PDB:2Q7X"
FT TURN 46..48
FT /evidence="ECO:0007829|PDB:2Q7X"
FT HELIX 56..64
FT /evidence="ECO:0007829|PDB:2Q7X"
FT HELIX 69..75
FT /evidence="ECO:0007829|PDB:2Q7X"
FT HELIX 94..104
FT /evidence="ECO:0007829|PDB:2Q7X"
FT HELIX 107..118
FT /evidence="ECO:0007829|PDB:2Q7X"
FT STRAND 122..130
FT /evidence="ECO:0007829|PDB:2Q7X"
FT STRAND 132..138
FT /evidence="ECO:0007829|PDB:2Q7X"
FT STRAND 143..146
FT /evidence="ECO:0007829|PDB:2Q7X"
FT HELIX 147..152
FT /evidence="ECO:0007829|PDB:2Q7X"
FT STRAND 157..166
FT /evidence="ECO:0007829|PDB:2Q7X"
FT HELIX 176..183
FT /evidence="ECO:0007829|PDB:2Q7X"
FT STRAND 185..189
FT /evidence="ECO:0007829|PDB:2Q7X"
FT HELIX 194..198
FT /evidence="ECO:0007829|PDB:2Q7X"
FT HELIX 199..202
FT /evidence="ECO:0007829|PDB:2Q7X"
FT HELIX 207..213
FT /evidence="ECO:0007829|PDB:2Q7X"
FT STRAND 215..221
FT /evidence="ECO:0007829|PDB:2Q7X"
FT HELIX 236..247
FT /evidence="ECO:0007829|PDB:2Q7X"
FT STRAND 253..258
FT /evidence="ECO:0007829|PDB:2Q7X"
FT HELIX 264..269
FT /evidence="ECO:0007829|PDB:2Q7X"
FT HELIX 283..289
FT /evidence="ECO:0007829|PDB:2Q7X"
FT STRAND 291..296
FT /evidence="ECO:0007829|PDB:2Q7X"
FT STRAND 299..302
FT /evidence="ECO:0007829|PDB:2Q7X"
FT STRAND 305..308
FT /evidence="ECO:0007829|PDB:2Q7X"
FT HELIX 310..320
FT /evidence="ECO:0007829|PDB:2Q7X"
SQ SEQUENCE 325 AA; 36033 MW; 6C0CEE663BABB17F CRC64;
MRKPKITVIG GGTGSPVILK SLREKDVEIA AIVTVADDGG SSGELRKNMQ QLTPPGDLRN
VLVAMSDMPK FYEKVFQYRF SEDAGAFAGH PLGNLIIAGL SEMQGSTYNA MQLLSKFFHT
TGKIYPSSDH PLTLHAVFQD GTEVAGESHI VDHRGIIDNV YVTNALNDDT PLASRRVVQT
ILESDMIVLG PGSLFTSILP NIVIKEIGRA LLETKAEIAY VCNIMTQRGE TEHFTDSDHV
EVLHRHLGRP FIDTVLVNIE KVPQEYMNSN RFDEYLVQVE HDFVGLCKQV SRVISSNFLR
LENGGAFHDG DLIVDELMRI IQVKK
